Mesenchymal and adrenergic cell lineage states in neuroblastoma possess distinct immunogenic phenotypes
Apart from the anti-GD2 antibody, immunotherapy for neuroblastoma has had limited
success due to immune evasion mechanisms, coupled with an incomplete understanding of …
success due to immune evasion mechanisms, coupled with an incomplete understanding of …
Reversible transitions between noradrenergic and mesenchymal tumor identities define cell plasticity in neuroblastoma
Noradrenergic and mesenchymal identities have been characterized in neuroblastoma cell
lines according to their epigenetic landscapes and core regulatory circuitries. However, their …
lines according to their epigenetic landscapes and core regulatory circuitries. However, their …
[PDF][PDF] The immune cell atlas of human neuroblastoma
BM Verhoeven, S Mei, TK Olsen, K Gustafsson… - Cell Reports …, 2022 - cell.com
Understanding the complete immune cell composition of human neuroblastoma (NB) is
crucial for the development of immunotherapeutics. Here, we perform single-cell RNA …
crucial for the development of immunotherapeutics. Here, we perform single-cell RNA …
Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma
Immune checkpoint inhibitors have been successful across several tumor types; however,
their efficacy has been uncommon and unpredictable in glioblastomas (GBM), where< 10 …
their efficacy has been uncommon and unpredictable in glioblastomas (GBM), where< 10 …
Transition to a mesenchymal state in neuroblastoma confers resistance to anti-GD2 antibody via reduced expression of ST8SIA1
Immunotherapy with anti-GD2 antibodies has advanced the treatment of children with high-
risk neuroblastoma, but nearly half of patients relapse, and little is known about mechanisms …
risk neuroblastoma, but nearly half of patients relapse, and little is known about mechanisms …
Tumor to normal single-cell mRNA comparisons reveal a pan-neuroblastoma cancer cell
Neuroblastoma is a childhood cancer that resembles developmental stages of the neural
crest. It is not established what developmental processes neuroblastoma cancer cells …
crest. It is not established what developmental processes neuroblastoma cancer cells …
Expression profiling of single cells and patient cohorts identifies multiple immunosuppressive pathways and an altered NK cell phenotype in glioblastoma
HJ Close, LF Stead, J Nsengimana… - Clinical & …, 2020 - academic.oup.com
Glioblastoma (GBM) is an aggressive cancer with a very poor prognosis. Generally viewed
as weakly immunogenic, GBM responds poorly to current immunotherapies. To understand …
as weakly immunogenic, GBM responds poorly to current immunotherapies. To understand …
[PDF][PDF] Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion
Glioblastoma multiforme (GBM) is an aggressive brain tumor for which current
immunotherapy approaches have been unsuccessful. Here, we explore the mechanisms …
immunotherapy approaches have been unsuccessful. Here, we explore the mechanisms …
Single-cell RNA sequencing reveals evolution of immune landscape during glioblastoma progression
Glioblastoma (GBM) is an incurable primary malignant brain cancer hallmarked with a
substantial protumorigenic immune component. Knowledge of the GBM immune …
substantial protumorigenic immune component. Knowledge of the GBM immune …
Immunotherapy of neuroblastoma: facts and hopes
While the adoption of multimodal therapy including surgery, radiation, and aggressive
combination chemotherapy has improved outcomes for many children with high-risk …
combination chemotherapy has improved outcomes for many children with high-risk …