Two human genetic tubulopathies, Bartter's (BS) and Gitelman's (GS) syndromes, have
normo/hypotension and absent cardiac remodeling despite their apparent angiotensin …

Abstract Background: Gitelman's and Bartter's syndromes (GS/BS) are rare genetic
tubulopathies characterized by electrolyte imbalance and activation of the renin-angiotensin …

Abstract Background. Bartter's and Gitelman's syndromes (BS/GS) have a blunted Gq
protein-mediated cell signalling despite high circulating angiotensin II (Ang II) levels. This is …

Reactive oxygen species (ROS) are intermediates in reduction–oxidation reactions that
begin with the addition of one electron to molecular oxygen, generating the primary ROS …

Abstract Introduction Extensive studies using Bartter's/Gitelman's syndrome patients have
provided insights into the angiotensin II (Ang II) signaling pathways involved in the …

Gitelman's syndrome (GS) and Bartter's syndrome (BS) are rare inherited salt-losing
tubulopathies whose variations in genotype do not correlate well with either clinical course …

Insights into the Angiotensin II (Ang II) signalling pathways have been provided by extensive
studies using Bartter's/Gitelman's syndromes patients. These syndromes are characterized …

In a recent article, Wolfrum et al1 have shown that in human cells in culture, inhibition of Rho
kinase (RKO) activates Akt pathway, which they contend leads to cardiovascular protection …

Objective Angiotensin II (Ang II)-mediated activation of Rho kinase (ROK) is involved in the
pathophysiology of hypertension and cardiovascular remodeling. ROK also controls …

Abstract Background. Angiotensin II (Ang II) is a powerful proinflammatory cytokine and
growth factor that activates NF-κB, as well as NAD (P) H oxidase, and thus is a key factor for …