Development of a vaccine to protect against cryptococcosis is a priority given the enormous
global burden of disease in at-risk individuals. Using glucan particles (GPs) as a delivery …

Meningitis due to Cryptococcus neoformans is responsible for upwards of 180,000 deaths
worldwide annually, mostly in immunocompromised individuals. Currently there are no …

ABSTRACT A vaccine capable of protecting at-risk persons against infections due to
Cryptococcus neoformans and Cryptococcus gattii could reduce the substantial global …

The high global burden of cryptococcosis has made development of a protective vaccine a
public health priority. We previously demonstrated that a vaccine composed of recombinant …

Cryptococcosis is a fungal disease caused by multiple Cryptococcus serotypes; particularly
C. neoformans (serotypes A and D) and C. gattii (serotypes B and C). To date, there is no …

Cryptococcus neoformans and C. gattii, the predominant etiological agents of
cryptococcosis, can cause life-threatening infections of the central nervous system in …

Galactoxylomannan (GalXM) is a complex polysaccharide produced by the human
pathogenic fungus Cryptococcus neoformans that mediates profound immunological …

Cryptococcosis remains a significant cause of morbidity and mortality world-wide,
particularly among AIDS patients. Yet, to date, there are no licensed vaccines clinically …

Cryptococcosis is a relatively common fungal disease caused by Cryptococcus neoformans
that has high morbidity and mortality. Numerous studies have established the feasibility of …

Infections due to the encapsulated fungus Cryptococcus neoformans are a significant cause
of morbidity and mortality in patients with impaired T-cell function, particularly those with …