Nuclear receptors linking metabolism, inflammation, and fibrosis in nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) and its progressive form nonalcoholic
steatohepatitis (NASH) comprise a spectrum of chronic liver diseases in the global …
steatohepatitis (NASH) comprise a spectrum of chronic liver diseases in the global …
Nonalcoholic fatty liver disease: pathogenesis and potential for nuclear receptors as therapeutic targets
J George, C Liddle - Molecular Pharmaceutics, 2008 - ACS Publications
Nonalcoholic fatty liver disease (NAFLD) is a consequence of insulin resistance
encompassing a spectrum that extends from simple hepatic steatosis through to …
encompassing a spectrum that extends from simple hepatic steatosis through to …
Nuclear receptors and nonalcoholic fatty liver disease
MC Cave, HB Clair, JE Hardesty, KC Falkner… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Nuclear receptors are transcription factors which sense changing environmental or
hormonal signals and effect transcriptional changes to regulate core life functions including …
hormonal signals and effect transcriptional changes to regulate core life functions including …
Immunity as cornerstone of non-alcoholic fatty liver disease: the contribution of oxidative stress in the disease progression
Non-alcoholic fatty liver disease (NAFLD) is considered the hepatic manifestation of
metabolic syndrome and has become the major cause of chronic liver disease, especially in …
metabolic syndrome and has become the major cause of chronic liver disease, especially in …
Nuclear receptor modulation for the treatment of nonalcoholic fatty liver disease
CD Fuchs, SA Traussnigg… - Seminars in liver …, 2016 - thieme-connect.com
Nuclear receptors (NRs) are ligand-activated transcriptional regulators of several key
metabolic processes including hepatic lipid and glucose metabolism, bile acid homeostasis …
metabolic processes including hepatic lipid and glucose metabolism, bile acid homeostasis …
Emerging molecular targets for treatment of nonalcoholic fatty liver disease
Z Chen, Y Yu, J Cai, H Li - Trends in Endocrinology & Metabolism, 2019 - cell.com
In parallel with the obesity epidemic, nonalcoholic fatty liver disease (NAFLD) has emerged
as the most common chronic liver disease worldwide. Disequilibrium of lipid metabolism and …
as the most common chronic liver disease worldwide. Disequilibrium of lipid metabolism and …
Anti-NASH drug development hitches a lift on PPAR agonism
J Boeckmans, A Natale, M Rombaut, K Buyl, V Rogiers… - Cells, 2019 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) affects one-third of the population worldwide, of
which a substantial number of patients suffer from non-alcoholic steatohepatitis (NASH) …
which a substantial number of patients suffer from non-alcoholic steatohepatitis (NASH) …
The role and mechanism of oxidative stress and nuclear receptors in the development of NAFLD
T Hong, Y Chen, X Li, Y Lu - Oxidative medicine and cellular …, 2021 - Wiley Online Library
The overproduction of reactive oxygen species (ROS) and consequent oxidative stress
contribute to the pathogenesis of acute and chronic liver diseases. It is now acknowledged …
contribute to the pathogenesis of acute and chronic liver diseases. It is now acknowledged …
Current options and future directions for NAFLD and NASH treatment
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide, with a broad spectrum ranging from simple steatosis to advanced stage of …
worldwide, with a broad spectrum ranging from simple steatosis to advanced stage of …
PPAR-γ signaling in nonalcoholic fatty liver disease: Pathogenesis and therapeutic targets
H Chen, H Tan, J Wan, Y Zeng, J Wang… - Pharmacology & …, 2023 - Elsevier
Non-alcoholic fatty liver disease (NAFLD), currently the leading cause of global chronic liver
disease, has emerged as a major public health problem, more efficient therapeutics of which …
disease, has emerged as a major public health problem, more efficient therapeutics of which …