A tractable, simplified ex vivo human skin model of wound infection
DJ Yoon, DR Fregoso, D Nguyen… - Wound Repair and …, 2019 - Wiley Online Library
The prevalence of infection in chronic wounds is well documented in the literature but not
optimally studied due to the drawbacks of current methodologies. Here, we describe a …
optimally studied due to the drawbacks of current methodologies. Here, we describe a …
Assessing Animal Models to Study Impaired and Chronic Wounds
S Saeed, M Martins-Green - International Journal of Molecular Sciences, 2024 - mdpi.com
Impaired healing wounds do not proceed through the normal healing processes in a timely
and orderly manner, and while they do eventually heal, their healing is not optimal. Chronic …
and orderly manner, and while they do eventually heal, their healing is not optimal. Chronic …
[HTML][HTML] Development, standardization and testing of a bacterial wound infection model based on ex vivo human skin
C Schaudinn, C Dittmann, J Jurisch, M Laue… - PLoS …, 2017 - journals.plos.org
Current research on wound infections is primarily conducted on animal models, which limits
direct transferability of these studies to humans. Some of these limitations can be overcome …
direct transferability of these studies to humans. Some of these limitations can be overcome …
Animal models of chronic wound care: the application of biofilms in clinical research
H Trøstrup, K Thomsen, H Calum, N Høiby… - Chronic Wound Care …, 2016 - Taylor & Francis
Chronic wounds are a substantial clinical problem affecting millions of people worldwide.
Pathophysiologically, chronic wounds are stuck in the inflammatory state of healing. The role …
Pathophysiologically, chronic wounds are stuck in the inflammatory state of healing. The role …
Preclinical models for wound-healing studies
I Pastar, L Liang, AP Sawaya, TC Wikramanayake… - Skin tissue models, 2018 - Elsevier
Cutaneous wound healing is an evolutionarily conserved and highly complex process that
restores the cutaneous barrier after injury. Experimental wound-healing models provide …
restores the cutaneous barrier after injury. Experimental wound-healing models provide …
Fighting chronic wound infection-one model at a time
Wound infections are a serious medical problem for patients with non-healing chronic
wounds and burn injuries. The healing of these wounds is often compromised by …
wounds and burn injuries. The healing of these wounds is often compromised by …
[HTML][HTML] Modeling Wound Chronicity In Vivo: The Translational Challenge to Capture the Complexity of Chronic Wounds
AL Pignet, M Schellnegger, A Hecker… - Journal of Investigative …, 2024 - Elsevier
In an aging society with common lifestyle-associated health issues such as obesity and
diabetes, chronic wounds pose a frequent challenge that physicians face in everyday …
diabetes, chronic wounds pose a frequent challenge that physicians face in everyday …
Animal models in chronic wound healing research: for innovations and emerging technologies in wound care
N Remoué, C Bonod, B Fromy… - … emerging technologies in …, 2020 - Elsevier
When wound healing is compromised resulting in wound healing delay or no healing at all,
it is a chronic wound and it puts at risk the body to infection and further health complications …
it is a chronic wound and it puts at risk the body to infection and further health complications …
Challenges with wound infection models in drug development
Wound research is an evolving science trying to unfold the complex untold mechanisms
behind the wound healing cascade. In particular, interest is growing regarding the role of …
behind the wound healing cascade. In particular, interest is growing regarding the role of …
Biofilms and inflammation in chronic wounds
G Zhao, ML Usui, SI Lippman, GA James… - Advances in wound …, 2013 - liebertpub.com
Significance: The incidence, cost, morbidity, and mortality associated with non-healing of
chronic skin wounds are dramatic. With the increasing numbers of people with obesity …
chronic skin wounds are dramatic. With the increasing numbers of people with obesity …