A tractable, simplified ex vivo human skin model of wound infection

DJ Yoon, DR Fregoso, D Nguyen… - Wound Repair and …, 2019 - Wiley Online Library
The prevalence of infection in chronic wounds is well documented in the literature but not
optimally studied due to the drawbacks of current methodologies. Here, we describe a …

Assessing Animal Models to Study Impaired and Chronic Wounds

S Saeed, M Martins-Green - International Journal of Molecular Sciences, 2024 - mdpi.com
Impaired healing wounds do not proceed through the normal healing processes in a timely
and orderly manner, and while they do eventually heal, their healing is not optimal. Chronic …

[HTML][HTML] Development, standardization and testing of a bacterial wound infection model based on ex vivo human skin

C Schaudinn, C Dittmann, J Jurisch, M Laue… - PLoS …, 2017 - journals.plos.org
Current research on wound infections is primarily conducted on animal models, which limits
direct transferability of these studies to humans. Some of these limitations can be overcome …

Animal models of chronic wound care: the application of biofilms in clinical research

H Trøstrup, K Thomsen, H Calum, N Høiby… - Chronic Wound Care …, 2016 - Taylor & Francis
Chronic wounds are a substantial clinical problem affecting millions of people worldwide.
Pathophysiologically, chronic wounds are stuck in the inflammatory state of healing. The role …

Preclinical models for wound-healing studies

I Pastar, L Liang, AP Sawaya, TC Wikramanayake… - Skin tissue models, 2018 - Elsevier
Cutaneous wound healing is an evolutionarily conserved and highly complex process that
restores the cutaneous barrier after injury. Experimental wound-healing models provide …

Fighting chronic wound infection-one model at a time

Z Kopecki, AJ Cowin - Wound Practice & Research: Journal of …, 2017 - search.informit.org
Wound infections are a serious medical problem for patients with non-healing chronic
wounds and burn injuries. The healing of these wounds is often compromised by …

[HTML][HTML] Modeling Wound Chronicity In Vivo: The Translational Challenge to Capture the Complexity of Chronic Wounds

AL Pignet, M Schellnegger, A Hecker… - Journal of Investigative …, 2024 - Elsevier
In an aging society with common lifestyle-associated health issues such as obesity and
diabetes, chronic wounds pose a frequent challenge that physicians face in everyday …

Animal models in chronic wound healing research: for innovations and emerging technologies in wound care

N Remoué, C Bonod, B Fromy… - … emerging technologies in …, 2020 - Elsevier
When wound healing is compromised resulting in wound healing delay or no healing at all,
it is a chronic wound and it puts at risk the body to infection and further health complications …

Challenges with wound infection models in drug development

SK Shukla, AK Sharma, V Gupta, A Kalonia… - Current drug …, 2020 - ingentaconnect.com
Wound research is an evolving science trying to unfold the complex untold mechanisms
behind the wound healing cascade. In particular, interest is growing regarding the role of …

Biofilms and inflammation in chronic wounds

G Zhao, ML Usui, SI Lippman, GA James… - Advances in wound …, 2013 - liebertpub.com
Significance: The incidence, cost, morbidity, and mortality associated with non-healing of
chronic skin wounds are dramatic. With the increasing numbers of people with obesity …