Engineering the multiscale complexity of vascular networks

C O'Connor, E Brady, Y Zheng, E Moore… - Nature Reviews …, 2022 - nature.com
The survival of vertebrate organisms depends on highly regulated delivery of oxygen and
nutrients through vascular networks that pervade nearly all tissues in the body …

From arteries to capillaries: approaches to engineering human vasculature

S Fleischer, DN Tavakol… - Advanced functional …, 2020 - Wiley Online Library
From microscaled capillaries to millimeter‐sized vessels, human vasculature spans multiple
scales and cell types. The convergence of bioengineering, materials science, and stem cell …

3D-printed fluidic networks as vasculature for engineered tissue

IS Kinstlinger, JS Miller - Lab on a Chip, 2016 - pubs.rsc.org
Fabrication of vascular networks within engineered tissue remains one of the greatest
challenges facing the fields of biomaterials and tissue engineering. Historically, the …

Microfabricated biomaterials for engineering 3D tissues

P Zorlutuna, N Annabi, G Camci‐Unal… - Advanced …, 2012 - Wiley Online Library
Mimicking natural tissue structure is crucial for engineered tissues with intended
applications ranging from regenerative medicine to biorobotics. Native tissues are highly …

Integrated approaches to spatiotemporally directing angiogenesis in host and engineered tissues

RJ Kant, KLK Coulombe - Acta biomaterialia, 2018 - Elsevier
The field of tissue engineering has turned towards biomimicry to solve the problem of tissue
oxygenation and nutrient/waste exchange through the development of vasculature …

Manufacturing the multiscale vascular hierarchy: progress toward solving the grand challenge of tissue engineering

EA Margolis, NE Friend, MW Rolle, E Alsberg… - Trends in …, 2023 - cell.com
In human vascular anatomy, blood flows from the heart to organs and tissues through a
hierarchical vascular tree, comprising large arteries that branch into arterioles and further …

Upgrading prevascularization in tissue engineering: a review of strategies for promoting highly organized microvascular network formation

D Sharma, D Ross, G Wang, W Jia, SJ Kirkpatrick… - Acta Biomaterialia, 2019 - Elsevier
Functional and perfusable vascular network formation is critical to ensure the long-term
survival and functionality of engineered tissues after their transplantation. Although several …

[PDF][PDF] Rapid fabrication of bio‐inspired 3D microfluidic vascular networks

JH Huang, J Kim, N Agrawal, AP Sudarsan… - Advanced …, 2009 - researchgate.net
Living systems face a fundamental challenge of orchestrating exchange of nutrients and
oxygen throughout 3D space in order to satisfy their metabolic needs.[1] In nature, vascular …

Engineering vascular self‐assembly by controlled 3D‐Printed cell placement

I Orellano, A Thomas, A Herrera… - Advanced Functional …, 2022 - Wiley Online Library
Nutrient supply via a functional vasculature is essential during regenerative processes,
tissue growth, and homeostasis. 3D bioprinting offers the opportunity to engineer …

Engineering the vasculature with additive manufacturing

C Vyas, R Pereira, B Huang, F Liu, W Wang… - Current Opinion in …, 2017 - Elsevier
Additive manufacturing encompasses a group of 3D printing technologies enabling the
generation of complex, biomimetic 3D structures for tissue engineering and regenerative …