Structural Modification Strategies of Triazoles in Anticancer Drug Development
Q Guan, Z Gao, Y Chen, C Guo, Y Chen… - European Journal of …, 2024 - Elsevier
The triazole functional group plays a pivotal role in the composition of biomolecules with
potent anticancer activities, including numerous clinically approved drugs. The strategic …
potent anticancer activities, including numerous clinically approved drugs. The strategic …
Recent advances in synthesis and anticancer potential of triazole-containing scaffolds
Cancer is the most lethal disease that may be found anywhere globally. Approximately 10%
of individuals die due to cancer of various types, with 19.3 million new cancer cases and 10 …
of individuals die due to cancer of various types, with 19.3 million new cancer cases and 10 …
Triazole Moieties as Potent Drug Molecules: Synthetic Approaches and Application as Promising Candidates as Anticancer Agents (A Review)
VK Vashistha, A Mittal, R Bala, R Pullabhotla - Russian Journal of …, 2023 - Springer
Despite considerable progress in the field of anticancer agent development, there remains a
demand for more efficacious and safer drugs. The utilization of current agents in cancer …
demand for more efficacious and safer drugs. The utilization of current agents in cancer …
1, 2, 3‐Triazole hybrids as anticancer agents: A review
MM Alam - Archiv der Pharmazie, 2022 - Wiley Online Library
Despite the advancements in the development of anticancer agents, more effective and
safer anticancer drugs still need to be developed as the current agents cause unwanted side …
safer anticancer drugs still need to be developed as the current agents cause unwanted side …
1, 2, 3-TRIAZOLE SCAFFOLD IN RECENT MEDICINAL APPLICATIONS: SYNTHESIS AND ANTICANCER POTENTIALS
V Choomuenwai, R Leechaisit, R Pingaew… - …, 2022 - mahidol.elsevierpure.com
Cancer is one of commonly concerned health problems globally and its management is
challenging. Besides an availability of diverse classes of anticancer agents, the existing …
challenging. Besides an availability of diverse classes of anticancer agents, the existing …
Current development of pyrazole–azole hybrids with anticancer potential
S Zhang, Y Ye, Q Zhang, Y Luo, ZC Wang… - Future Medicinal …, 2023 - Taylor & Francis
Chemotherapy is a critical treatment modality for cancer patients, but multidrug resistance
remains one of the major challenges in cancer therapy, creating an urgent need for the …
remains one of the major challenges in cancer therapy, creating an urgent need for the …
1, 2, 3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships
Z Xu, SJ Zhao, Y Liu - European journal of medicinal chemistry, 2019 - Elsevier
Anticancer agents are critical for the cancer treatment, but side effects and the drug
resistance associated with the currently used anticancer agents create an urgent need to …
resistance associated with the currently used anticancer agents create an urgent need to …
Tetrazole: A privileged scaffold for the discovery of anticancer agents
A Verma, B Kaur, S Venugopal… - Chemical Biology & …, 2022 - Wiley Online Library
Carcinoma, characterized by abnormal growth of cells and tissue, is a ubiquitously leading
cause of mortality across the globe due to some carcinogenic factors. Currently, several …
cause of mortality across the globe due to some carcinogenic factors. Currently, several …
Synthesis and anticancer properties of 'azole'based chemotherapeutics as emerging chemical moieties: A comprehensive review
Azole frameworks serve as privileged scaffolds in the contemporary drug design paradigm
owing to their unique physicochemical profile that promotes the development of highly …
owing to their unique physicochemical profile that promotes the development of highly …
Triazoles and their derivatives: Chemistry, synthesis, and therapeutic applications
Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior
pharmacological applications. Structurally, there are two types of five-membered triazoles: 1 …
pharmacological applications. Structurally, there are two types of five-membered triazoles: 1 …