Abstract Purpose Hyper Immunoglobulin M (HIgM) syndrome is a heterogeneous group of
primary immunodeficiency disorders, characterized by recurrent infections and associated …

Hyper-IgM (HIGM) syndrome is a heterogeneous group of disorders characterized by normal
or elevated serum IgM levels associated with absent or decreased IgG, IgA and IgE. Here …

Abstract Hyper Immunoglobulin M syndrome (HIGM) is a rare primary immunodeficiency
disorder characterized by low or absent levels of serum IgG, IgA, IgE and normal or …

Abstract Background: Hyper-immunoglobulin M (HIGM) syndrome is a rare heterogeneous
group of primary immunodeficiency disorders characterized by low or absent serum levels of …

Abstract Purpose Hyper-IgM syndrome due to CD40 deficiency (HIGM3) is a rare form of
primary immunodeficiency with few reported cases. In this study, we further characterize the …

Abstract Purpose The United States Immunodeficiency Network (USIDNET) patient registry
was used to characterize the presentation, genetics, phenotypes, and treatment of patients …

Abstract Background Hyper-immunoglobulin M (HIGM) syndromes are a heterogeneous
group of primary immunodeficiency disorders, characterized by recurrent infections …

Very high IgM levels represent the hallmark of hyper IgM (HIGM) syndromes, a group of
primary immunodeficiencies (PIDs) characterized by susceptibility to infections and …

Background: Defects in B cell class switch recombination (CSR) are a heterogeneous and
yet very uncommon group of disorders which all have a genetic basis uniformly leading to …

ABSTRACT Background: Hyper IgM Syndrome (HIGM) is a rare primary immunodeficiency
in which impairment of class switching recombination (CSR) and somatic hyper-mutation …