[HTML][HTML] Curcumin and andrographis exhibit anti-tumor effects in colorectal cancer via activation of ferroptosis and dual suppression of glutathione peroxidase-4 and …
Colorectal cancer (CRC) is the leading cause of cancer-related deaths worldwide. The
limitations of current chemotherapeutic drugs in CRC include their toxicity, side effects, and …
limitations of current chemotherapeutic drugs in CRC include their toxicity, side effects, and …
Curcumin Represses Colorectal Cancer Cell Proliferation by Triggering Ferroptosis via PI3K/Akt/mTOR Signaling
M Chen, A Tan, J Li - Nutrition and Cancer, 2023 - Taylor & Francis
Curcumin is known to suppress the progression of colorectal cancer by inhibiting cancer cell
proliferation. In this study, we explored the role of ferroptosis in the antiproliferative …
proliferation. In this study, we explored the role of ferroptosis in the antiproliferative …
Impact of curcumin on ferroptosis‐related genes in colorectal cancer: Insights from in‐silico and in‐vitro studies
AA Firouzjaei, SH Aghaee‐Bakhtiari… - Cell Biochemistry …, 2023 - Wiley Online Library
Colorectal cancer (CRC) is responsible for a significant number of cancer‐related fatalities
worldwide. Researchers are investigating the therapeutic potential of ferroptosis, a type of …
worldwide. Researchers are investigating the therapeutic potential of ferroptosis, a type of …
Andrographis-mediated chemosensitization through activation of ferroptosis and suppression of β-catenin/Wnt-signaling pathways in colorectal cancer
Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality in
the USA. As much as 50–60% of CRC patients develop resistance to 5-fluorouracil (5FU) …
the USA. As much as 50–60% of CRC patients develop resistance to 5-fluorouracil (5FU) …
Curcumin induces ferroptosis in A549 CD133+ cells through the GSH-GPX4 and FSP1-CoQ10-NAPH pathways
J Zhou, L Zhang, J Yan, A Hou, W Sui… - Discovery …, 2023 - pubmed.ncbi.nlm.nih.gov
Background Cancer stem cells (CSCs) are characterized by an ability for unlimited
proliferation and efficiency of self-renewal. The targeting of lung CSCs (LCSCs)-related …
proliferation and efficiency of self-renewal. The targeting of lung CSCs (LCSCs)-related …
[HTML][HTML] Enhanced anti-cancer activity of andrographis with oligomeric proanthocyanidins through activation of metabolic and ferroptosis pathways in colorectal cancer
The high degree of morbidity and mortality in colorectal cancer (CRC) patients is largely due
to the development of chemoresistance against conventional chemotherapeutic drugs. In …
to the development of chemoresistance against conventional chemotherapeutic drugs. In …
Osthole inhibits malignant phenotypes and induces ferroptosis in KRAS-mutant colorectal cancer cells via suppressing AMPK/Akt signaling
X Zhou, J Kang, L Zhang, Y Cheng - Cancer Chemotherapy and …, 2023 - Springer
Purpose Ferroptosis is a form of cell death driven by iron-dependent lipid peroxidation.
Intriguingly, KRAS-mutant cancers are particularly vulnerable to ferroptosis. Osthole is a …
Intriguingly, KRAS-mutant cancers are particularly vulnerable to ferroptosis. Osthole is a …
Luteolin exhibits synergistic therapeutic efficacy with erastin to induce ferroptosis in colon cancer cells through the HIC1-mediated inhibition of GPX4 expression
Y Zheng, L Li, H Chen, Y Zheng, X Tan, G Zhang… - Free Radical Biology …, 2023 - Elsevier
Colon cancer continues to be a prevalent gastrointestinal malignancy with a bleak
prognosis. The induction of ferroptosis, a new form of regulated cell death, has emerged as …
prognosis. The induction of ferroptosis, a new form of regulated cell death, has emerged as …
[HTML][HTML] Nrf2 inhibition increases sensitivity to chemotherapy of colorectal cancer by promoting ferroptosis and pyroptosis
Y Huang, W Yang, L Yang, T Wang, C Li, J Yu… - Scientific reports, 2023 - nature.com
Oxaliplatin is widely used in chemotherapy for colorectal cancer (CRC), but its sensitivity has
become a major obstacle to limiting efficacy. Many literatures reported that Nrf2 activation …
become a major obstacle to limiting efficacy. Many literatures reported that Nrf2 activation …
Ginsenoside Rh4 inhibits colorectal cancer cell proliferation by inducing ferroptosis via autophagy activation
Y Wu, D Pi, Y Chen, Q Zuo, S Zhou… - Evidence‐Based …, 2022 - Wiley Online Library
Colorectal cancer (CRC) is a severe threat to human health. Ginsenosides such as
ginsenoside Rh4 have been widely studied in the antitumor field. Here, we investigated the …
ginsenoside Rh4 have been widely studied in the antitumor field. Here, we investigated the …
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