[HTML][HTML] Curcumin and andrographis exhibit anti-tumor effects in colorectal cancer via activation of ferroptosis and dual suppression of glutathione peroxidase-4 and …

K Miyazaki, C Xu, M Shimada, A Goel - Pharmaceuticals, 2023 - mdpi.com
Colorectal cancer (CRC) is the leading cause of cancer-related deaths worldwide. The
limitations of current chemotherapeutic drugs in CRC include their toxicity, side effects, and …

Curcumin Represses Colorectal Cancer Cell Proliferation by Triggering Ferroptosis via PI3K/Akt/mTOR Signaling

M Chen, A Tan, J Li - Nutrition and Cancer, 2023 - Taylor & Francis
Curcumin is known to suppress the progression of colorectal cancer by inhibiting cancer cell
proliferation. In this study, we explored the role of ferroptosis in the antiproliferative …

Impact of curcumin on ferroptosis‐related genes in colorectal cancer: Insights from in‐silico and in‐vitro studies

AA Firouzjaei, SH Aghaee‐Bakhtiari… - Cell Biochemistry …, 2023 - Wiley Online Library
Colorectal cancer (CRC) is responsible for a significant number of cancer‐related fatalities
worldwide. Researchers are investigating the therapeutic potential of ferroptosis, a type of …

Andrographis-mediated chemosensitization through activation of ferroptosis and suppression of β-catenin/Wnt-signaling pathways in colorectal cancer

P Sharma, T Shimura, JK Banwait, A Goel - Carcinogenesis, 2020 - academic.oup.com
Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality in
the USA. As much as 50–60% of CRC patients develop resistance to 5-fluorouracil (5FU) …

Curcumin induces ferroptosis in A549 CD133+ cells through the GSH-GPX4 and FSP1-CoQ10-NAPH pathways

J Zhou, L Zhang, J Yan, A Hou, W Sui… - Discovery …, 2023 - pubmed.ncbi.nlm.nih.gov
Background Cancer stem cells (CSCs) are characterized by an ability for unlimited
proliferation and efficiency of self-renewal. The targeting of lung CSCs (LCSCs)-related …

[HTML][HTML] Enhanced anti-cancer activity of andrographis with oligomeric proanthocyanidins through activation of metabolic and ferroptosis pathways in colorectal cancer

T Shimura, P Sharma, GG Sharma, JK Banwait… - Scientific Reports, 2021 - nature.com
The high degree of morbidity and mortality in colorectal cancer (CRC) patients is largely due
to the development of chemoresistance against conventional chemotherapeutic drugs. In …

Osthole inhibits malignant phenotypes and induces ferroptosis in KRAS-mutant colorectal cancer cells via suppressing AMPK/Akt signaling

X Zhou, J Kang, L Zhang, Y Cheng - Cancer Chemotherapy and …, 2023 - Springer
Purpose Ferroptosis is a form of cell death driven by iron-dependent lipid peroxidation.
Intriguingly, KRAS-mutant cancers are particularly vulnerable to ferroptosis. Osthole is a …

Luteolin exhibits synergistic therapeutic efficacy with erastin to induce ferroptosis in colon cancer cells through the HIC1-mediated inhibition of GPX4 expression

Y Zheng, L Li, H Chen, Y Zheng, X Tan, G Zhang… - Free Radical Biology …, 2023 - Elsevier
Colon cancer continues to be a prevalent gastrointestinal malignancy with a bleak
prognosis. The induction of ferroptosis, a new form of regulated cell death, has emerged as …

[HTML][HTML] Nrf2 inhibition increases sensitivity to chemotherapy of colorectal cancer by promoting ferroptosis and pyroptosis

Y Huang, W Yang, L Yang, T Wang, C Li, J Yu… - Scientific reports, 2023 - nature.com
Oxaliplatin is widely used in chemotherapy for colorectal cancer (CRC), but its sensitivity has
become a major obstacle to limiting efficacy. Many literatures reported that Nrf2 activation …

Ginsenoside Rh4 inhibits colorectal cancer cell proliferation by inducing ferroptosis via autophagy activation

Y Wu, D Pi, Y Chen, Q Zuo, S Zhou… - Evidence‐Based …, 2022 - Wiley Online Library
Colorectal cancer (CRC) is a severe threat to human health. Ginsenosides such as
ginsenoside Rh4 have been widely studied in the antitumor field. Here, we investigated the …