Pancreatic ductal adenocarcinoma (PDA) cells reprogram both mitochondrial and lysosomal
functions to support growth. At the same time, this causes significant dishomeostasis of free …

Hypoxia and nutrient starvation (H/NS) microenvironment, a notable characteristic of
pancreatic carcinoma, plays a critical role in cell death resistance and tumor recurrence …

Pancreatic ductal adenocarcinoma (PDAC) is an extremely lethal cancer with limited
treatment options. Cisplatin (DDP) is used as a mainstay of chemotherapeutic agents in …

Although induction of ferroptosis, an iron-dependent form of non-apoptotic cell death, has
emerged as an anticancer strategy, the metabolic basis of ferroptotic death remains poorly …

Emerging evidence suggests that selenium has chemotherapeutic potential by inducing
cancer cell apoptosis with minimal side effects to normal cells. However, the mechanism by …

Ferroptosis is a type of regulated cell death that displays a promising therapeutic pathway
for drug‐resistant tumor cells. However, some pancreatic cancer (PC) cells are less sensitive …

Redox active selenium (Se) compounds have gained substantial attention in the last decade
as potential cancer therapeutic agents. Several Se compounds have shown high selectivity …

As cancer cells develop resistance to apoptosis, non-apoptotic cell death modalities, such
as ferroptosis, have emerged as promising strategies to combat therapy-resistant cancers …

Pancreatic ductal adenocarcinoma (PDAC) remains an aggressive malignancy with a 5-year
survival rate below 10%. Its unique genetic makeup and tumor microenvironment produce a …

Pancreatic ductal adenocarcinoma is the main cause of cancer-related mortality, with a lack
of effective treatments and overall survival rates far lower than other solid cancers. This …