We recently have identified an antigen receptor in sharks called NAR (n ew or n urse shark a
ntigen r eceptor) that is secreted by splenocytes but does not associate with Ig light (L) …

The immunoglobulin new antigen receptors (IgNARs) are a class of Ig-like molecules of the
shark immune system that exist as heavy chain-only homodimers and bind antigens by their …

The new antigen receptor (NAR) from nurse sharks consists of an immunoglobulin variable
domain attached to five constant domains, and is hypothesised to function as an antigen …

The Ig new antigen receptors (IgNARs) are single-domain antibodies found in the serum of
sharks. Here, we report 2.2-and 2.8-Å structures of the type 2 IgNAR variable domains 12Y-1 …

The new antigen receptor (IgNAR) family has been detected in all elasmobranch species so
far studied and has several intriguing structural and functional features. IgNAR protein …

The new antigen receptor (NAR) gene in the nurse shark diversifies extensively by somatic
hypermutation. It is not known, however, whether NAR somatic hypermutation generates the …

Distinctive Ig and T cell receptor (TcR) chains define the two major lineages of vertebrate
lymphocyte yet similarly recognize antigen with a single, membrane-distal variable (V) …

The new antigen receptor (IgNAR) antibodies from sharks are disulphide bonded dimers of
two protein chains, each containing one variable and five constant domains. Three types of …

The single variable new antigen receptor domain antibody fragments (VNARs) derived from
shark immunoglobulin new antigen receptor antibodies (IgNARs) represent some of the …

The antigen binding variable domain (VNAR) of the shark immunoglobulin new antigen
receptor (IgNAR) evolved approximately 500 million years ago and it is one of the smallest …