Background The use of percutaneous coronary intervention (PCI) in patients with ST‐
segment elevation myocardial infarction (STEMI) is associated with a mortality rate of 5 …

Different types of ATP-sensitive K+ (KATP) channels have been identified in cardiomyocytes,
vascular smooth muscle cells, pancreatic β-cells, neurons and mitochondria. Years before …

Objectives: This study aimed to examine: 1) whether nicorandil protects the ischemic
myocardium by activating sarcolemmal adenosine triphosphate (ATP)-sensitive K+ …

The roles of cardiomyocyte sarcolemmal ATP-sensitive K+ (KATP) and mitochondrial KATP
channels in the cardioprotection and antiarrhythmic activity induced by KATP channel …

Recently, much interest has been focused on the pharmacology of ATP-sensitive potassium
channels (KATP) in myocardial ischemia. KATP are thought to be involved with the …

Cardioprotection by K ATP channel openers during ischemia is well documented although ill
understood. Proarrhythmic effects may be an important drawback. K ATP channel …

Mitochondria are being increasingly studied for their critical role in cell survival. Multiple
diverse signaling pathways have been shown to converge on the K+-sensitive ATP …

ATP-dependent potassium channels (KATP) have been implicated in cardioprotection both
during myocardial ischemia and reperfusion. We compared the effect of a non-selective …

We investigated the effect of ATP-sensitive K+ channel (KATP) openers (pinacidil and
cromakalim), and a KATP blocker (glibenclamide) on reperfusion-induced arrhythmias in …

During ischemia, ATP-sensitive K+ channels (KATP channels) open, and this triggers
necrotic processes and apoptosis. In this study, we investigated whether selective …