INTRODUCTION The faithful replication and segregation of chromosomes as part of the cell
division cycle requires that topological changes be imposed upon cellular DNA …

Biochi~ic~a Page 1 ELSEVIER Biochimica et Biophysica Acta 1262 (1995) 1-14 BB Biochi~ic~a
et Biophysica A~ta Review Eukaryotic DNA topoisomerases I Malini Gupta, Akira Fujimori …

Recent structural and mechanistic studies, as well as the discovery of new enzymes in the
DNA topoisomerase family, allow these enzymes to be classified into three groups. Each …

Publisher Summary Topoisomerases are a diverse and important group of enzymes.
Although attention has until recently been focused on their ability to interconvert DNA …

Molecular Biology and Plant Physiology, University of Aarhus, DK-8000 Arhus C, Denmark
Received February 27, 1989; Revised Manuscript Received April 28, 1989 abstract: The …

The intertwining of the two strands of the DNA helix presents a number of topological
problems which the cell must overcome in order to regenerate, recombine, and express its …

▪ Abstract DNA topoisomerases solve the topological problems associated with DNA
replication, transcription, recombination, and chromatin remodeling by introducing …

Type IA and type II DNA topoisomerases are distinguished by their ability to cleave one or
two strands, respectively, of a DNA duplex. Both types have been proposed to use an …

The topological state of DNA, and the enzymes that control this state, play a crucial role in
determining the function of DNA in cells; In eukaryotes, DNA supercoiling is an essential …

Although the genetic code is defined by a linear array of nucleotides, it is the three‐
dimensional structure of the double helix that regulates most of its cellular functions. Over …