Multiethnic meta-analysis of genome-wide association studies in> 100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal …
Background—Estimates of the heritability of plasma fibrinogen concentration, an established
predictor of cardiovascular disease, range from 34% to 50%. Genetic variants so far …
predictor of cardiovascular disease, range from 34% to 50%. Genetic variants so far …
Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts
Background—Fibrinogen is both central to blood coagulation and an acute-phase reactant.
We aimed to identify common variants influencing circulation fibrinogen levels. Methods and …
We aimed to identify common variants influencing circulation fibrinogen levels. Methods and …
A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration
PS De Vries, DI Chasman… - Human molecular …, 2016 - academic.oup.com
Genome-wide association studies have previously identified 23 genetic loci associated with
circulating fibrinogen concentration. These studies used HapMap imputation and did not …
circulating fibrinogen concentration. These studies used HapMap imputation and did not …
Associations between common fibrinogen gene polymorphisms and cardiovascular disease in older adults
Elevated plasma fibrinogen is a risk factor for cardiovascular disease (CVD), but
associations between fibrinogen single nucleotide polymorphisms (SNPs) and disease risk …
associations between fibrinogen single nucleotide polymorphisms (SNPs) and disease risk …
Genes encoding fibrinogen and cardiovascular risk
L Iacoviello, M Vischetti, F Zito, M Benedetta Donati - Hypertension, 2001 - Am Heart Assoc
The role of fibrinogen in cardiovascular disease has been extensively studied, and meta-
analyses have definitively confirmed that high levels of fibrinogen are associated with an …
analyses have definitively confirmed that high levels of fibrinogen are associated with an …
Does elevated plasma fibrinogen increase the risk of coronary heart disease? Evidence from a meta-analysis of genetic association studies
Objective—The purpose of this study was to assess whether a genetic variant associated
with higher fibrinogen levels is associated with increased coronary heart disease (CHD) risk …
with higher fibrinogen levels is associated with increased coronary heart disease (CHD) risk …
Association of genomic loci from a cardiovascular gene SNP array with fibrinogen levels in European Americans and African-Americans from six cohort studies: the …
CL Wassel, LA Lange, BJ Keating… - Blood, The Journal …, 2011 - ashpublications.org
Several common genomic loci, involving various immunity-and metabolism-related genes,
have been associated with plasma fibrinogen in European Americans (EAs). The genetic …
have been associated with plasma fibrinogen in European Americans (EAs). The genetic …
[HTML][HTML] Association between patterns of nucleotide variation across the three fibrinogen genes and plasma fibrinogen levels: the Coronary Artery Risk Development …
AP Reiner, CL Carty, CS Carlson, JY Wan… - Journal of Thrombosis …, 2006 - Elsevier
Background: Previous genotype–phenotype association studies of fibrinogen have been
limited by incomplete knowledge of genomic sequence variation within and between major …
limited by incomplete knowledge of genomic sequence variation within and between major …
Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the …
JS Danik, G Paré, DI Chasman, RYL Zee… - Circulation …, 2009 - Am Heart Assoc
Background—Fibrinogen is a multifunctional circulating glycoprotein involved in wound
healing, thrombosis, platelet aggregation, and inflammation, and elevated levels predict …
healing, thrombosis, platelet aggregation, and inflammation, and elevated levels predict …
Assessment of genetic determinants of the association of γ′ fibrinogen in relation to cardiovascular disease
RS Lovely, Q Yang, JM Massaro, J Wang… - … , and vascular biology, 2011 - Am Heart Assoc
Objective—γ′ fibrinogen is a newly emerging biomarker that is associated with
cardiovascular disease (CVD). However, the genetic determinants of γ′ fibrinogen levels …
cardiovascular disease (CVD). However, the genetic determinants of γ′ fibrinogen levels …