The bacterial enzyme RppH initiates mRNA decay by removing pyrophosphate from 5΄-
triphosphorylated mRNA. Escherichia coli RppH has promiscuous substrate specificity, but …

Background: In bacteria, RppH triggers mRNA degradation by converting the 5′-terminal
triphosphate to a monophosphate. Results: The substrate specificity of E. coli RppH has …

Deprotection of the 5′ end appears to be a universal mechanism for triggering the
degradation of mRNA in bacteria and eukaryotes. In Escherichia coli, for example …

The mRNA degradation is an important regulatory mechanism which controls gene
expression by limiting the number of translation times. Previous studies demonstrated that …

Similar to decapping of eukaryotic mRNAs, the RppH-catalyzed conversion of 5′-terminal
triphosphate to monophosphate has recently been identified as the rate-limiting step for the …

Background: RppH initiates mRNA degradation in bacteria by removing pyrophosphate from
the triphosphorylated 5′ terminus. Results: X-ray structures of E. coli RppH have revealed …

In E scherichia coli, the endonuclease RNase E can access internal cleavage sites in mRNA
either directly or by a 5′ end‐dependent mechanism in which cleavage is facilitated by …

Bacterial RNA degradation often begins with conversion of the 5′-terminal triphosphate to
a monophosphate, creating a better substrate for subsequent ribonuclease digestion. For …

Abstract mRNA decay is an important strategy by which bacteria can rapidly adapt to their
ever-changing surroundings. The 5′-terminus state of mRNA determines the velocity of …

RNA modifications that once escaped detection are now thought to be pivotal for governing
RNA lifetimes in both prokaryotes and eukaryotes. For example, converting the 5′-terminal …