Prokaryotic transcription factors (TFs) that bind small xenobiotic molecules (eg, TFs that
drive genes that respond to environmental pollutants) often display a promiscuous effector …

A subgenomic array of structural and regulatory genes of the TOL plasmid pWW0 of
Pseudomonas putida mt‐2 has been constructed to sort out the interplay between m‐xylene …

To investigate the activation mechanism of the enhancer‐binding protein XylR encoded by
the TOL plasmid of Pseudomonas putida mt‐2, a combinatorial library was generated …

Background The genetic network of the TOL plasmid pWW0 of the soil bacterium
Pseudomonas putida mt-2 for catabolism of m-xylene is an archetypal model for …

The expression dynamics of the catabolic promoters of the TOL plasmid pWW0 has been
examined in single cells of Pseudomonas putida mt‐2 exposed to m‐xylene. To this end, we …

XylR is a σ54‐dependent transcriptional factor of Pseudomonas putida that activates the Pu
promoter of the TOL plasmid upon binding its natural effector, m‐xylene. The search for …

The first mechanistic description of gene expression control was proposed by Jacob and
Monod (1961) for the lac operon of E. coli. The first version of the model contemplated …

The TOL system encoded by plasmid pWW0 of P seudomonas putida mt‐2 is able to sense
a large number of both exogenous and endogenous signals as inputs for the genetic and …

Evolutionary expansion of metabolic networks entails the emergence of regulatory factors
that become sensitive to new chemical species. A dedicated genetic system was developed …

The activation of the Pm promoter of the meta operon of the TOL plasmid of Pseudomonas
putida by its cognate XylS activator protein in the presence and absence of benzoate …