Enhancing Fractionated Cancer Therapy: A Triple-Anthracene Photosensitizer Unleashes Long-Persistent Photodynamic and Luminous Efficacy

Y Wang, H Shen, Z Li, S Liao, B Yin… - Journal of the …, 2024 - ACS Publications
Conventional photodynamic therapy (PDT) is often limited in treating solid tumors due to
hypoxic conditions that impede the generation of reactive oxygen species (ROS), which are …

Supramolecular photosensitizer enables oxygen-independent generation of hydroxyl radicals for photodynamic therapy

KX Teng, LY Niu, QZ Yang - Journal of the American Chemical …, 2023 - ACS Publications
The highly oxygen-dependent nature of photodynamic therapy (PDT) limits its therapeutic
efficacy against hypoxic solid tumors in clinics, which is an urgent problem to be solved …

In vitro demonstration of the heavy-atom effect for photodynamic therapy

A Gorman, J Killoran, C O'Shea, T Kenna… - Journal of the …, 2004 - ACS Publications
Photodynamic therapy (PDT) is an emerging treatment modality for a range of disease
classes, both cancerous and noncancerous. This has brought about an active pursuit of new …

Innovative strategies for enhanced tumor photodynamic therapy

G Li, Q Wang, J Liu, M Wu, H Ji, Y Qin… - Journal of Materials …, 2021 - pubs.rsc.org
Photodynamic therapy (PDT) is an approved and promising treatment approach that utilizes
a photosensitizer (PS) to produce cytotoxic reactive oxygen species (ROS) through …

Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

Z Zhou, J Song, L Nie, X Chen - Chemical society reviews, 2016 - pubs.rsc.org
The reactive oxygen species (ROS)-mediated mechanism is the major cause underlying the
efficacy of photodynamic therapy (PDT). The PDT procedure is based on the cascade of …

Recent progress in photosensitizers for overcoming the challenges of photodynamic therapy: from molecular design to application

X Zhao, J Liu, J Fan, H Chao, X Peng - Chemical Society Reviews, 2021 - pubs.rsc.org
Photodynamic therapy (PDT), a therapeutic mode involving light triggering, has been
recognized as an attractive oncotherapy treatment. However, nonnegligible challenges …

Supramolecular photosensitizers rejuvenate photodynamic therapy

X Li, S Lee, J Yoon - Chemical Society Reviews, 2018 - pubs.rsc.org
Owing to its spatiotemporal selectivity and noninvasive nature, photodynamic therapy (PDT)
has become a clinically promising approach for the treatment of a wide range of cancers and …

Tailoring photosensitive ROS for advanced photodynamic therapy

DL Sai, J Lee, DL Nguyen, YP Kim - Experimental & molecular …, 2021 - nature.com
Photodynamic therapy (PDT) has been considered a noninvasive and cost-effective
modality for tumor treatment. However, the complexity of tumor microenvironments poses …

Enhanced photodynamic therapy for overcoming tumor hypoxia: From microenvironment regulation to photosensitizer innovation

J Du, T Shi, S Long, P Chen, W Sun, J Fan… - Coordination Chemistry …, 2021 - Elsevier
Photodynamic therapy (PDT) has garnered an increasing interest by both researchers and
clinicians as a non-invasive therapy that allows a selective treatment towards tumors …

Innovative strategies for hypoxic‐tumor photodynamic therapy

X Li, N Kwon, T Guo, Z Liu… - Angewandte Chemie …, 2018 - Wiley Online Library
Despite its clinical promise, photodynamic therapy (PDT) suffers from a key drawback
associated with its oxygen‐dependent nature, which limits its effective use against hypoxic …