Staphylococcal enterotoxins modulate the effector CD4+ T cell response by reshaping the gene expression profile in adults with atopic dermatitis

RL Orfali, FSY Yoshikawa, LMS Oliveira, NZ Pereira… - Scientific reports, 2019 - nature.com
Staphylococcus aureus colonizes the skin of atopic dermatitis (AD) individuals, but the
impact of its enterotoxins on the chronic activation of CD4+ T cells demands further analysis …

Effects of topical application of a recombinant staphylococcal enterotoxin A on DNCB and dust mite extract-induced atopic dermatitis-like lesions in a murine model

BS Kim, JK Choi, HJ Jung, KH Park, YH Jang… - European Journal of …, 2014 - Springer
Background Atopic dermatitis (AD) is a chronic inflammatory skin disease with biphasic T
cell-mediated abnormalities. Staphylococcal superantigens contribute to the exacerbation of …

Alpha‐toxin is produced by skin colonizing Staphylococcus aureus and induces a T helper type 1 response in atopic dermatitis

K Breuer, M Wittmann, K Kempe, A Kapp… - Clinical & …, 2005 - Wiley Online Library
Background Staphylococcus aureus is a well known trigger factor of atopic dermatitis (AD).
Besides the superantigens, further exotoxins are produced by S. aureus and may have an …

Staphylococcal enterotoxin induced IL‐5 stimulation as a cofactor in the pathogenesis of atopic disease: the hygiene hypothesis in reverse?

T Heaton, D Mallon, T Venaille, P Holt - Allergy, 2003 - Wiley Online Library
Background: The incidence of Staphylococcus aureus (S. aureus) colonization on the skin of
patients with atopic eczema/dermatitis syndrome (AEDS) is approximately 90% and a variety …

Staphylococcal α-toxin induces a higher T cell proliferation and interleukin-31 in atopic dermatitis

M Niebuhr, D Mamerow, A Heratizadeh… - International archives of …, 2011 - karger.com
Background: Patients with atopic dermatitis (AD) are frequently colonized with α-toxin-
producing Staphylococcus aureus which is in turn positively correlated with the severity of …

Staphylococcal enterotoxin B induces specific IgG4 and IgE antibody serum levels in atopic dermatitis

RL Orfali, MN Sato, VG Santos, TO Titz… - International Journal …, 2015 - Wiley Online Library
Background Atopic dermatitis (AD) is a chronic recurrent inflammatory disease, with
prevalence of about 10–20% in children and 1–3% in adults. S taphylococcus aureus is …

Human dendritic cells conditioned with Staphylococcus aureus enterotoxin B promote TH2 cell polarization

M Mandron, MF Ariès, RD Brehm, HS Tranter… - Journal of allergy and …, 2006 - Elsevier
BACKGROUND: Immune surveillance against microbes at sites of interface with
environment involves immediate recognition of pathogen-associated molecular patterns by …

Effects of the Staphylococcus aureus and Staphylococcus epidermidis Secretomes Isolated from the Skin Microbiota of Atopic Children on CD4+ T Cell Activation

E Laborel-Préneron, P Bianchi, F Boralevi, P Lehours… - PLoS …, 2015 - journals.plos.org
Interactions between the immune system and skin bacteria are of major importance in the
pathophysiology of atopic dermatitis (AD), yet our understanding of them is limited. From a …

Increased expression of Toll-Like Receptor (TLR) 2 and TLR6 on peripheral blood monocytes by induction of Staphylococcal enterotoxin B during exacerbation of …

F Salim, H Gunawan, O Suwarsa… - Clinical, Cosmetic and …, 2023 - Taylor & Francis
Background Atopic dermatitis (AD) is a chronic and recurrent inflammatory skin disease that
can be triggered by various precipitating factors, including colonization by Staphylococcus …

DS–Nh as an experimental model of atopic dermatitis induced by Staphylococcus aureus producing staphylococcal enterotoxin C

T Yoshioka, I Hikita, T Matsutani, R Yoshida… - …, 2003 - Wiley Online Library
DS–Nh mice raised under conventional conditions spontaneously develop dermatitis similar
to human atopic dermatitis (AD), which is associated with staphylococcal infection. In the …