The hypothesis that cancer is driven by tumour-initiating cells (popularly known as cancer
stem cells) has recently attracted a great deal of attention, owing to the promise of a novel …

Background: Until few years ago, all neoplastic cells within a tumour were suggested to
have tumorigenic capacity, but recent evidences hint to the possibility that such feature is …

Cancer has long been viewed as a heterogeneous population of cells. While the great
majority of cells that make up tumors are destined to differentiate, albeit aberrantly, and …

Cancer is the second leading cause for mortality in US only after heart disease and lacks a
good or effective therapeutic paradigm. Despite the emergence of new, targeted agents and …

Cancer stem cells have been identified in a variety of tumors. Characterization of these cells,
determining how they originate and developing relevant assays is a work in progress …

Cancer stem cells (CSCs) are a subpopulation of tumor cells that selectively possess tumor
initiation and self-renewal capacity and the ability to give rise to bulk populations of …

Over the past two decades, major advances in our understanding of cancer have translated
into only modest increments in survival for the majority of cancer patients. Recent data …

Cancer stem cells are a progressive concept to account for the cell biological nature of
cancer. Despite the controversies regarding the cancer stem cell model, it has the potential …

There is growing realization that many–if not all–cancer-cell populations contain a
subpopulation of self-renewing stem cells known as cancer stem cells (CSCs). Unlike …

Although the concept that cancers arise from “stem cells” or “germ cells” was first proposed
about 150 years ago, it is only recently that advances in stem cell biology have given new …