[HTML][HTML] Targeting regulated cell death (RCD) with small-molecule compounds in triple-negative breast cancer: a revisited perspective from molecular mechanisms to …

M Liao, R Qin, W Huang, HP Zhu, F Peng… - Journal of Hematology & …, 2022 - Springer
Triple-negative breast cancer (TNBC) is a subtype of human breast cancer with one of the
worst prognoses, with no targeted therapeutic strategies currently available. Regulated cell …

Small-molecule drug discovery in triple negative breast cancer: current situation and future directions

M Liao, J Zhang, G Wang, L Wang, J Liu… - Journal of medicinal …, 2021 - ACS Publications
Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, but
an effective targeted therapy has not been well-established so far. Considering the lack of …

Treatment landscape of triple-negative breast cancer—Expanded options, evolving needs

G Bianchini, C De Angelis, L Licata… - Nature reviews Clinical …, 2022 - nature.com
Tumour heterogeneity and a long-standing paucity of effective therapies other than
chemotherapy have contributed to triple-negative breast cancer (TNBC) being the subtype …

[HTML][HTML] Druggable molecular targets for the treatment of triple negative breast cancer

M Nakhjavani, JE Hardingham… - Journal of breast …, 2019 - ncbi.nlm.nih.gov
Breast cancer (BC) is still the most common cancer among women worldwide. Amongst the
subtypes of BC, triple negative breast cancer (TNBC) is characterized by deficient …

[HTML][HTML] The fate of chemoresistance in triple negative breast cancer (TNBC)

EA O'Reilly, L Gubbins, S Sharma, R Tully, MHZ Guang… - BBA clinical, 2015 - Elsevier
Background Treatment options for women presenting with triple negative breast cancer
(TNBC) are limited due to the lack of a therapeutic target and as a result, are managed with …

Recent progress in small molecule agents for the targeted therapy of triple-negative breast cancer

R Islam, KW Lam - European journal of medicinal chemistry, 2020 - Elsevier
Triple-negative breast cancer (TNBC) is the most aggressive type of cancer, with a high risk
of death on recurrence. To date, there is a lack of approved targeted agents for the treatment …

[HTML][HTML] How shall we treat early triple-negative breast cancer (TNBC): from the current standard to upcoming immuno-molecular strategies

JH Park, JH Ahn, SB Kim - ESMO open, 2018 - Elsevier
Triple-negative breast cancer (TNBC) is a long-lasting orphan disease in terms of little
therapeutic progress during the past several decades and still the standard of care remains …

[HTML][HTML] Targeted therapeutic strategies for triple-negative breast cancer

Y Li, Z Zhan, X Yin, S Fu, X Deng - Frontiers in oncology, 2021 - frontiersin.org
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer,
which is characterized by the lack of clinically significant expression of estrogen receptor …

[HTML][HTML] Recent therapeutic trends and promising targets in triple negative breast cancer

SY Hwang, S Park, Y Kwon - Pharmacology & therapeutics, 2019 - Elsevier
Breast cancer accounts for 25% of all types of cancer in women, and triple negative breast
cancer (TNBC) comprises around 15~ 20% of breast cancers. Conventional chemotherapy …

[HTML][HTML] Targeting oncogenic vulnerabilities in triple negative breast cancer: biological bases and ongoing clinical studies

A Ocana, A Pandiella - Oncotarget, 2017 - ncbi.nlm.nih.gov
Triple negative breast cancer (TNBC) is still an incurable disease despite the great scientific
effort performed during the last years. The huge heterogeneity of this disease has motivated …