The long-term effects of opioids on sensitization processes are believed to be mediated
through the N-methyl-D-aspartate receptor. Quantitative sensory testing (QST) changes …

Chronic pain patients who are treated with opioid therapy represent a significant challenge
to medical professionals. When pain recurs in the face of a previously effective opioid …

Objective The aim of this study was to compare the sensitivity to experimental pain of chronic
pain patients on opioid therapy vs chronic pain patients on non-opioid therapy and healthy …

Ketamine is a noncompetitive N-methyl-D-aspartate (NMDA) receptor channel blocker
known to inhibit" wind-up" and hence central hyperexcitability of dorsal horn neurons. We …

1. What is the conventional practice? 2. Are there reasonable alternatives to COT? 3. What is
the risk of adverse events? 4. Is the patient likely to be a responsible drug-taker? Question 4 …

Inhibitory and facilitatory descending pathways, originating at higher central nervous system
sites, modulate activity of dorsal horn nociceptive neurons, and thereby influence pain …

Preclinical studies have suggested that opioid exposure may induce a paradoxical decrease
in the nociceptive threshold, commonly referred as opioid-induced hyperalgesia (OIH) …

The large inter-individual variability in the magnitude of analgesia in response to opioids
and the high prevalence of adverse events associated with their use underline the clinical …

Abstract Editor's Perspective What We Already Know about This Topic Ketamine is an N-
methyl-d-aspartate antagonist with growing use in the management of chronic pain …

Background Ketamine is a dissociative anesthetic with analgesic properties. Ketamine's
analgesic properties have been suggested to result from its dissociative properties. To the …