Underdiagnoses and undertreatment of osteoporosis: the battle to be won

PD Miller - The Journal of Clinical Endocrinology & Metabolism, 2016 - academic.oup.com
Context: An expert opinion perspective on why osteoporosis is underdiagnosed and
undertreated. Objective: To highlight the potential reasons for why osteoporosis is …

Bisphosphonate Use and Risk of Atypical Femoral Fractures: A Danish Case-Cohort Study With Blinded Radiographic Review

DC Bauer, DM Black, R Dell, B Fan… - The Journal of …, 2024 - academic.oup.com
Context Prolonged bisphosphonate (BP) treatment for osteoporosis prevents hip and other
fractures but causes atypical femoral fractures (AFF). Objective To establish the relationship …

Bisphosphonates and risk of subtrochanteric, femoral shaft, and atypical femur fracture: a systematic review and meta‐analysis

L Gedmintas, DH Solomon… - Journal of bone and …, 2013 - academic.oup.com
Although there is strong evidence that bisphosphonates prevent certain types of
osteoporotic fractures, there are concerns that these medications may be associated with …

Increased risk for atypical fractures associated with bisphosphonate use

S Lee, RV Yin, H Hirpara, NC Lee, A Lee… - Family …, 2015 - academic.oup.com
Background: Studies suggest an increasing occurrence of atypical femoral fractures with the
use of bisphosphonates. Objective: To examine whether the use of bisphosphonates …

Atypical femur fractures: review of epidemiology, relationship to bisphosphonates, prevention, and clinical management

DM Black, B Abrahamsen, ML Bouxsein… - Endocrine …, 2019 - academic.oup.com
Bisphosphonates (BPs) are highly effective in treating osteoporosis and reducing hip,
vertebral, and other fractures by as much as 50% to 70%. However, since 2006, atypical …

Bisphosphonate therapy and atypical fractures

A Saleh, VV Hegde, AG Potty… - Orthopedic Clinics, 2013 - orthopedic.theclinics.com
Bisphosphonates are a mainstay of therapy for osteoporosis. Several studies have
documented their efficacy in preventing both vertebral and nonvertebral fractures. 1–4 With …

Addressing the crisis in the treatment of osteoporosis: a path forward

S Khosla, JA Cauley, J Compston… - Journal of Bone and …, 2017 - academic.oup.com
Considerable data and media attention have highlighted a potential “crisis” in the treatment
of osteoporosis. Specifically, despite the availability of several effective drugs to prevent …

Osteoporosis: how long should we treat?

A Sebba - Current Opinion in Endocrinology, Diabetes and …, 2008 - journals.lww.com
Osteoporosis: how long should we treat? : Current Opinion in Endocrinology, Diabetes and
Obesity Osteoporosis: how long should we treat? : Current Opinion in Endocrinology …

[HTML][HTML] Evolving data about subtrochanteric fractures and bisphosphonates

E Shane - N Engl J Med, 2010 - natap.org
Osteoporosis, a skeletal disorder characterized by reduced bone strength that predisposes
to an increased risk of fracture, affects 10 to 12 million people in the United States. In 2000 …

[HTML][HTML] Atypical femur fracture risk versus fragility fracture prevention with bisphosphonates

DM Black, EJ Geiger, R Eastell… - … England Journal of …, 2020 - Mass Medical Soc
Background Bisphosphonates are effective in reducing hip and osteoporotic fractures.
However, concerns about atypical femur fractures have contributed to substantially …