The aldol reaction is one of the most important methods for the stereoselective construction
of polyketide natural products, not only for nature but also for synthetic chemistry. The …

Polyketides have long provided synthetic organic chemists with a variety of complex
architectures to construct and develop new chemical tools for, and provided medicine with …

The synthesis of complex natural products still remains as the bottleneck for the biological
evaluation of such compounds. In contrast to the biosyntheses, vinylogous aldol reactions …

Covering: 1973 to the end of 2013 The vinylogous Mukaiyama aldol reaction (VMAR) allows
efficient access to larger segments for complex natural product synthesis, primarily …

This report details our discovery of a new catalytic ester aldol reaction using malonic acid
half thioesters (MAHTs) that directly affords β-hydroxythioesters. The reaction is catalyzed by …

The aldol addition reaction has become a strategically important, reliable transformation that
is widely employed in the asymmetric synthesis of complex molecules. It can be counted on …

The abundance, structural diversity, and significant biological activity of polyketide-derived
natural products has placed at the forefront of chemistry and biology the identification and …

The ability of amino acids to form nucleophilic enamines with aldehydes and ketones has
been used in the development of asymmetric α-oxidation reactions with electrophilic …

This feature article gives an overview of iterative synthetic methods for the construction of
deoxypropionates, an important class of polyketides. The catalytic and non-catalytic …

Many polyketide-derived natural products contain a syn-or anti-1, 3-diol unit. No general and
simple approach exists for the flexible synthesis of polyols and other polyketide-derived …