Background A significant portion of cancers are accounted for by a heritable component,
which has increasingly been linked to mutations in specific genes. Clinical interventions …

Conventional surgery in the treatment of solid tumors suggests a recently declining trend.
Endoscopic and laparoscopic techniques are increasingly replacing traditional surgery as …

Abstract Purpose and Methods Most patients who harbor a genetic mutation for hereditary
breast cancer have not been identified, despite the availability of genetic testing. Developing …

Purpose The reclassification of genetic variants poses a significant challenge for
laboratories and clinicians. Variant review has resulted in the reclassification of variants of …

The past two decades have brought many important advances in our understanding of the
hereditary susceptibility to cancer. Approximately 5–10% of all cancers are inherited, the …

Results Clinical criteria are currently available according to which many hereditary cancer
syndromes can be diagnosed or suspected and which point the way to further molecular …

Women with germline mutations in the cancer susceptibility genes, BRCA1 or BRCA2,
associated with Hereditary Breast & Ovarian Cancer syndrome, have up to an 85% lifetime …

Cancer genetics is increasingly becoming integrated into the practice of modern medical
oncology. The ability to distinguish a growing proportion of the 5% to 10% of all cancers that …

Hereditary cancer syndromes result from germline genetic alterations predisposing
individuals to higher lifetime cancer risk than the general population. Hereditary cancer …

Cancer is the second leading cause of death in both men and women in the United States,
with colorectal cancer and breast cancer being two of the most frequent cancer types …