Methotrexate has been used in treatment of rheumatoid arthritis (RA) since the 1980s and to
this day is often the first line medication for RA treatment. In this review, we examine multiple …

Despite the introduction of numerous biologic agents for the treatment of rheumatoid arthritis
(RA) and other forms of inflammatory arthritis, low-dose methotrexate therapy remains the …

Methotrexate remains a cornerstone in the treatment of rheumatoid arthritis and other
rheumatic diseases. Folate antagonism is known to contribute to the antiproliferative effects …

Methotrexate (MTX) has been used for the treatment of rheumatoid arthritis (RA) for about
forty years and to date MTX remains the part of global standard of treatment for RA. The …

OBJECTIVES:: To provide an update of the current knowledge of the mechanism ofaction of
low-dose methotrexate (MTX) in the treatment of patients with rheumatoid arthritis (RA), with …

As one of the most utilized disease-modifying anti-rheumatic drugs, methotrexate (MTX) has
revolutionized the treatment of rheumatoid arthritis as well as many other non-rheumatic …

This review presents recent data supporting the methotrexate (MTX) mechanisms of action,
which are likely to account for its anti-proliferative and immunosuppressive effects in …

Low-dose, weekly methotrexate is now standard second-line therapy for rheumatoid arthritis.
Methotrexate is the single agent to which new agents or combinations of agents have been …

A variety of disease-modifying antirheumatic drugs (DMARDs) are available to control the
clinical activity of rheumatoid arthritis (RA). Methotrexate (MTX), an analogue of folic acid …

The improvement of rheumatoid arthritis (RA) management has been strictly related to
methotrexate (MTX) long-term effectiveness, safety profile and its widespread use in clinical …