Though the cause of cystic fibrosis (CF) pathology is understood to be the mutation of the
CFTR protein, it has been difficult to trace the exact mechanisms by which the pathology …

The cystic fibrosis transmembrane regulator (CFTR) should no longer be viewed primarily as
a 'chloride channel'but recognized as a channel that also controls the efflux of other …

CFTR mutation, which causes cystic fibrosis (CF), has also recently been identified as
causing glutathione system dysfunction and systemic deficiency of reduced glutathione …

Many of the symptoms of cystic fibrosis are not explained by the current disease
mechanisms. Therefore, the authors conducted an extensive literature review and present a …

Cystic fibrosis (CF), a multisystem disease caused by CFTR (cystic fibrosis transmembrane
conductance regulator) gene mutations, is associated with an abnormal inflammatory …

Cystic fibrosis (CF), a disorder characterized by mutations of the CF transmembrane
regulator gene, is characterized in the lung by chronic inflammation, leading to progressive …

Studies have shown that expression of cystic fibrosis transmembrane conductance regulator
(CFTR) is associated with enhanced glutathione (GSH) efflux from airway epithelial cells …

There is substantial evidence in the literature that patients with cystic fibrosis (CF) have
higher oxidative stress than patients with other diseases or healthy subjects. This results in …

Glutathione (GSH) is a potentially important component of antioxidant defense in the
epithelial lung lining fluid. Cystic fibrosis (CF) patients have chronic inflammation in which …

Cystic fibrosis (CF) is a common, life-threatening, multisystemic, autosomal recessive
disorder. In the last few years, giant steps have been made with regard to the understanding …