Mitochondrial dysfunction is the pivotal driving factor of multiple inflammatory diseases, and
targeting mitochondrial biogenesis represents an efficacious approach to ameliorate such …

Macrophage recruitment and pro-inflammatory differentiation are hallmarks of various
diseases, including infection and sepsis. Although studies suggest that mitochondria may …

A growing body of evidence indicates that cellular metabolism is involved in immune cell
functions, including cytokine production. Serine is a nutritionally non-essential amino acid …

Inflammation is a natural reaction of the innate immune system that evolved primarily to
protect the human body from invading pathogens and to heal injuries. There are two …

Immune cell function depends on specific metabolic programs dictated by mitochondria,
including nutrient oxidation, macromolecule synthesis, and post-translational modifications …

Mitochondria are critical for regulation of the activation, differentiation, and survival of
macrophages and other immune cells. In response to various extracellular signals, such as …

Mitochondria are signaling hubs in cellular physiology that play a role in inflammatory
diseases. We found that partial inhibition of the mitochondrial ATP synthase in the intestine …

Activated macrophages undergo metabolic reprogramming, which drives their pro-
inflammatory phenotype, but the mechanistic basis for this remains obscure. Here, we …

Significance: The growing importance of mitochondria in the immune response and
inflammation is multifaceted. Unraveling the different mechanisms by which mitochondria …

The ability of mitochondria to transform the energy we obtain from food into cell
phosphorylation potential has long been appreciated. However, recent decades have seen …