During our genomic era, the landscape of somatic mutations has been largely studied in
several types of carcinomas, producing evidences that the mutation spectra can be different …

Enzymes of the family apolipoprotein B mRNA-editing enzyme catalytic polypeptidelike
(APOBEC) cytidine deaminases, which inhibit retroviruses by converting cytosine residues …

APOBEC enzymes are strong mutagenic factors. In breast cancer, expression of APOBEC3B
is increased and associated with mutation load and poor outcome. Other APOBEC3s can …

A major source of mutation in cancer is DNA cytosine deamination by APOBEC3 enzymes
resulting in C-to-T and C-to-G mutations in TCA and TCT motifs. Here, we develop a …

A prominent source of mutation in cancer is single-stranded DNA cytosine deamination by
cellular APOBEC3 enzymes, which results in C-to-T and C-to-G mutations in TCA and TCT …

A prominent source of mutation in cancer is single-stranded DNA cytosine deamination by
cellular APOBEC3 enzymes, which results in signature C-to-T and C-to-G mutations in TCA …

APOBEC3B, in addition to other members of the APOBEC3 gene family, has recently been
intensively studied due to its identification as a gene whose activation in cancer is …

The somatic mutations in a cancer genome are the aggregate outcome of one or more
mutational processes operative through the lifetime of the individual with cancer,,. Each …

Genomic sequencing studies of breast and other cancers have identified patterns of
mutations that have been attributed to the endogenous mutator activity of APOBEC3B (A3B) …

Purpose APOBEC3B belongs to the family of DNA-editing enzymes. A copy number variant
targeting the genomic APOBEC3A-APOBEC3B locus has a significant impact on breast …