Genome-wide DNA methylation reprogramming in response to inorganic arsenic links inhibition of CTCF binding, DNMT expression and cellular transformation
M Rea, M Eckstein, R Eleazer, C Smith… - Scientific reports, 2017 - nature.com
Chronic low dose inorganic arsenic (iAs) exposure leads to changes in gene expression
and epithelial-to-mesenchymal transformation. During this transformation, cells adopt a …
and epithelial-to-mesenchymal transformation. During this transformation, cells adopt a …
[HTML][HTML] Transient and permanent changes in DNA methylation patterns in inorganic arsenic-mediated epithelial-to-mesenchymal transition
M Eckstein, M Rea, YN Fondufe-Mittendorf - Toxicology and applied …, 2017 - Elsevier
Chronic low dose inorganic arsenic exposure causes cells to take on an epithelial-to-
mesenchymal phenotype, which is a crucial process in carcinogenesis. Inorganic arsenic is …
mesenchymal phenotype, which is a crucial process in carcinogenesis. Inorganic arsenic is …
[HTML][HTML] Selective inhibition of CTCF binding by iAs directs TET-mediated reprogramming of 5-hydroxymethylation patterns in iAs-transformed cells
M Rea, T Gripshover, Y Fondufe-Mittendorf - Toxicology and applied …, 2018 - Elsevier
Methylation at cytosine (5mC) is a fundamental epigenetic DNA modification recently
associated with iAs-mediated carcinogenesis. In contrast, the role of 5 …
associated with iAs-mediated carcinogenesis. In contrast, the role of 5 …
Inorganic Arsenic-induced cellular transformation is coupled with genome wide changes in chromatin structure, transcriptome and splicing patterns
C Riedmann, Y Ma, M Melikishvili, SG Godfrey… - BMC genomics, 2015 - Springer
Abstract Background Arsenic (As) exposure is a significant worldwide environmental health
concern. Low dose, chronic arsenic exposure has been associated with a higher than …
concern. Low dose, chronic arsenic exposure has been associated with a higher than …
CTCF loss mediates unique DNA hypermethylation landscapes in human cancers
NA Damaschke, J Gawdzik, M Avilla, B Yang… - Clinical …, 2020 - Springer
Background The chromatin insulator CCCTC-binding factor (CTCF) displays tissue-specific
DNA binding sites that regulate transcription and chromatin organization. Despite evidence …
DNA binding sites that regulate transcription and chromatin organization. Despite evidence …
Dysregulation of DNA methylation induced by past arsenic treatment causes persistent genomic instability in mammalian cells
M Mauro, F Caradonna, CB Klein - … and molecular mutagenesis, 2016 - Wiley Online Library
The mechanisms by which arsenic‐induced genomic instability is initiated and maintained
are poorly understood. To investigate potential epigenetic mechanisms, in this study we …
are poorly understood. To investigate potential epigenetic mechanisms, in this study we …
[HTML][HTML] DNA methylation regulates alternative polyadenylation via CTCF and the cohesin complex
Dysregulation of DNA methylation and mRNA alternative cleavage and polyadenylation
(APA) are both prevalent in cancer and have been studied as independent processes. We …
(APA) are both prevalent in cancer and have been studied as independent processes. We …
Unraveling the functional role of DNA demethylation at specific promoters by targeted steric blockage of DNA methyltransferase with CRISPR/dCas9
DM Sapozhnikov, M Szyf - Nature Communications, 2021 - nature.com
Despite four decades of research to support the association between DNA methylation and
gene expression, the causality of this relationship remains unresolved. Here, we reaffirm that …
gene expression, the causality of this relationship remains unresolved. Here, we reaffirm that …
A genome-scale map of DNA methylation turnover identifies site-specific dependencies of DNMT and TET activity
PA Ginno, D Gaidatzis, A Feldmann, L Hoerner… - Nature …, 2020 - nature.com
DNA methylation is considered a stable epigenetic mark, yet methylation patterns can vary
during differentiation and in diseases such as cancer. Local levels of DNA methylation result …
during differentiation and in diseases such as cancer. Local levels of DNA methylation result …
Editing DNA methylation in the mammalian genome
Mammalian DNA methylation is a critical epigenetic mechanism orchestrating gene
expression networks in many biological processes. However, investigation of the functions …
expression networks in many biological processes. However, investigation of the functions …