Breach of the skin barrier and subsequent wound healing occur in the context of microbial
communities of bacteria, fungi, and viruses. These polymicrobial communities are dynamic …

The skin barrier protects the human body from invasion by exogenous and pathogenic
microorganisms. A breach in this barrier exposes the underlying tissue to microbial …

The ecological community of microorganisms in/on humans, termed the microbiome, is vital
for sustaining homeostasis. While culture-independent techniques have revealed the role of …

Significance: Bacterial burden is believed to play a significant role in impaired wound
healing of chronic wounds and the development of infection-related complications. The …

Abstract Purpose of Review Microbial infections in chronic wounds can often lead to lower-
limb amputation, decrease in quality of life, and increase in mortality rate, and there is an …

The skin microbiota is intimately coupled with cutaneous health and disease. Interactions
between commensal microbiota and the multiple cell types involved in cutaneous wound …

Microbes colonizing and/or infecting chronic wounds undoubtedly play a major and
interactive role in impaired healing, especially in amplifying and perpetuating the host innate …

Significance: Culture-independent methods have revealed the diverse and dynamic
bacterial communities that colonize chronic wounds. Only recently have studies begun to …

Chronic, nonhealing wounds place an enormous burden on both the health care system and
patients, with no definitive treatments available. There has been increasing evidence that …

Wound healing is a highly coordinated and complex process, and there can be devastating
consequences if it is interrupted. It is believed that, in combination with host factors …