Networks of molecular regulators are often the primary objects of focus in the study of gene
regulation, with the machinery of protein synthesis tacitly relegated to the background …

Gene expression is regulated by specific transcriptional circuits but also by the global
expression machinery as a function of growth. Simultaneous specific and global regulation …

Microorganisms adjust metabolic activity to cope with diverse environments. While many
studies have provided insights into how individual pathways are regulated, the mechanisms …

One of the key ways in which microbes are thought to regulate their metabolism is by
modulating the availability of enzymes through transcriptional regulation. However, the …

BACKGROUND: Growth rate management in fast-growing bacteria is currently an active
research area. In spite of the huge progress made in our understanding of the molecular …

Highlights•Genes and genetic circuits exhibit growth-rate dependence.•Growth rate
dependence reflects coupling of gene expression and physiological state of the cell.•Several …

While previous studies have shed light on the link between the structure of metabolism and
its transcriptional regulation, the extent to which transcriptional regulation controls …

Transcription networks consist of hundreds of transcription factors with thousands of often
overlapping target genes. While we can reliably measure gene expression changes, we still …

In bacteria, the rate of cell proliferation and the level of gene expression are intimately
intertwined. Elucidating these relations is important both for understanding the physiological …

The recognition of carbon sources and the regulatory adjustments to recognized changes
are of particular importance for bacterial survival in fluctuating environments. Despite a …