Acute nociceptive pain is a key defence system that enables the detection of danger signals
that threaten homeostasis and survival. However, chronic pain (such as the neuropathic …

Pain is a defense system that responds rapidly to harmful internal and external stimuli
through the somatosensory neuronal pathway. However, damage to the nervous system …

Microglia play pivotal roles in controlling CNS functions in diverse physiological and
pathological contexts, including neuropathic pain, a chronic pain condition caused by …

Interactions between central glial cells and neurons in the pain circuitry are critical
contributors to the pathogenesis of chronic pain. In the central nervous system (CNS), two …

Introduction: Current pharmacotherapeutics for neuropathic pain offer only symptomatic
relief without treating the underlying pathophysiology. Additionally, they are associated with …

The microglia, once thought only to be supporting cells of the central nervous system (CNS),
are now recognized to play essential roles in many pathologies. Many studies within the last …

Chronic pain is a debilitating condition that often emerges as a clinical symptom of
inflammatory diseases. It has therefore been widely accepted that the immune system …

In contrast to physiological pain, pathological pain is not dependent on the presence of
tissue‐damaging stimuli. One type of pathological pain—neuropathic pain—is often a …

While spinal microglia play a role in early stages of neuropathic pain etiology, whether they
are useful targets to reverse chronic pain at late stages remains unknown. Here, we show …

The previous decade has seen a rapid increase in microglial studies on pain, with a unique
focus on microgliosis in the spinal cord after nerve injury and neuropathic pain. Numerous …