Purines and pyrimidines are indispensable molecules of life; they are fundamental for
genetic code and bioenergetics. From the very early evolution of life purines have acquired …

The purinergic signalling system, which utilises ATP, related nucleotides and adenosine as
transmitter molecules, appeared very early in evolution: release mechanisms and ATP …

Purines appear to be the most primitive and widespread chemical messengers in the animal
and plant kingdoms. The evidence for purinergic signalling in plants, invertebrates and …

In this Introduction to the series of papers that follow about purinergic receptors, there is a
brief history of the discovery of purinergic signalling, the identity of purinoceptors and the …

The purinergic signalling system is one of the most ancient and arguably the most
widespread intercellular signalling system in living tissues. In this review we present a …

New Findings• What is the topic of this review? This is a personal historical review about the
discovery and the main conceptual advances leading to our current understanding of …

This article attempts to paint a broad picture of the extraordinary explosive recent
developments in the purinergic signaling field. After a brief historical review and update of …

In the first 20 years that followed the purinergic signalling hypothesis in 1972, most scientists
were sceptical about its validity, largely because ATP was so well established as an …

The majority of studies of the functional distribution of purinoceptors have been carried out
with mammalian preparations. The objective of this article is to review the disparate literature …

Purinergic receptors, represented by several families, are arguably the most abundant
receptors in living organisms and appeared early in evolution. After slow acceptance …