Early detection of biofilms is crucial for limiting infection-based damage. Imaging these
biofilms is challenging: conventional imaging agents are unable to penetrate the dense …

Biofilms are complex structures with an intricate relationship between the resident
microorganisms, the extracellular matrix, and the surrounding environment. Interest in …

Identification of infectious bacteria responsible for biofilm-associated infections is
challenging due to the complex and heterogeneous biofilm matrix. To address this issue and …

Attached bacterial communities can generate three-dimensional (3D) physicochemical
gradients that create microenvironments where local conditions are substantially different …

Bacterial infections have posed a grave challenge to public health. Molecular fluorescent
probes play increasing important roles in diagnosis and treatment of bacterial infections, but …

Molecular mapping of live biofilms at submicrometer resolution presents a grand challenge.
Here, we present the first chemical mapping results of biofilm extracellular polymeric …

Currently optical-based techniques for in vivo microbial population imaging are limited by
low imaging depth and highly light-scattering tissue; and moreover, are generally effective …

Despite advances in monitoring spatiotemporal expression patterns of genes and proteins
with fluorescent probes, direct detection of metabolites and small molecules remains …

Bacterial biofilms are responsible for a wide range of persistent infections. In the clinic,
diagnosis of biofilm-associated infections relies heavily on culturing methods, which fail to …

Bacterial biofilms colonize chronic wounds and surfaces of medical devices, thus making the
development of reliable methods for imaging and detection of biofilms crucial. Although …