Because of the heterogeneity and complexity of tumor structure, cancer drugs often cannot
effectively reach the tumor, which is one of the reasons for drug resistance and treatment …

Highlights•Ideal mass spectrometer for MALDI MSI would satisfy the '4S-criteria for
performance'(speed, specificity, spatial resolution and sensitivity).•Quantification MALDI MSI …

Requirements for patient safety and improved efficacy are steadily increasing in modern
healthcare and are key drivers in modern drug development. New drug characterization …

The concentration and distribution of a drug or its metabolites in tissues are key factors for
understanding drug efficacy or toxicity. Conventional pharmacokinetic studies show that the …

Advances in development of mass spectrometry (MS) are successfully utilized for spatial
localization of pharmaceutical compounds in these tissue sections. Today MS instruments …

The matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI)
technique has attracted intense interest in the visualization of drug distribution in tissues. Its …

Matrix-assisted laser desorption/ionization (MALDI) is a soft ionization technique which can
be used in mass spectrometry to produce ions from biomolecules without inducing the …

The imaging of drugs inside tissues is pivotal in oncology to assess whether a drug reaches
all cells in an adequate enough concentration to eradicate the tumor. Matrix-Assisted Laser …

MALDI mass spectrometry imaging (MSI) provides a technology platform that allows the
accurate visualization of unlabeled small molecules within the two-dimensional spaces of …

Matrix-Assisted Laser Desorption/Ionization (MALDI) imaging has emerged as a powerful
analytical technique, enabling direct tissue imaging in pharmaceutical research. This review …