NSAIDs are extensively used worldwide; nonetheless, they are associated with adverse
gastrointestinal (GI) effects. COX-2 inhibitors (coxibs) have been developed to reduce pain …

Abstract Selective COX-2 inhibitors (coxibs) are approved for the relief of acute pain and
symptoms of chronic inflammatory conditions such as osteoarthritis (OA) and rheumatoid …

Reason for posting: Coxibs, the class of NSAIDs that selectively inhibit cyclooxygenase 2
(COX-2), were designed to reduce joint pain and inflammation without causing the gastric …

Objective: Further understand the safety profile of celecoxib and provide safety information
for important adverse events (AEs). Methods: Analysis of randomized controlled trials from …

Therapeutic Advances in Chronic Disease 9 (5) 108 journals. sagepub. com/home/taj via
COX-1. 15 In keeping with this, all nonaspirin NSAIDs and coxibs12, 16 seem to increase …

Non-selective NSAIDs enhance the risk of serious ulcer complications (bleeding,
perforation, obstruction), hospitalization and death about 3-10-fold. The gastrointestinal side …

Nonsteroidal anti-inflammatory drugs (NSAIDs) are responsible for substantial morbidity and
mortality as a result of the complications associated with gastroduodenal ulcers, such as …

In a very short time, COX-2 enzyme inhibitors have gone from the darlings to the pariahs of
the pharmaceutical industry. These drugs were developed based on the hypothesis …

Nonsteroidal anti-inflammatory drugs (NSAIDs) are effective for the relief of pain and
inflammation, yet their use is tempered by the development of side effects, primarily in the …

Prostanoids act leading roles in a myriad of physiologic and pathologic processes because
these autacoids participate in the amplification of biological responses induced by …