Clinical pharmacology of celecoxib, a COX-2 selective inhibitor
K Antoniou, M Malamas, AA Drosos - Expert opinion on …, 2007 - Taylor & Francis
NSAIDs are extensively used worldwide; nonetheless, they are associated with adverse
gastrointestinal (GI) effects. COX-2 inhibitors (coxibs) have been developed to reduce pain …
gastrointestinal (GI) effects. COX-2 inhibitors (coxibs) have been developed to reduce pain …
Clinical use and pharmacological properties of selective COX-2 inhibitors
S Shi, U Klotz - European journal of clinical pharmacology, 2008 - Springer
Abstract Selective COX-2 inhibitors (coxibs) are approved for the relief of acute pain and
symptoms of chronic inflammatory conditions such as osteoarthritis (OA) and rheumatoid …
symptoms of chronic inflammatory conditions such as osteoarthritis (OA) and rheumatoid …
New restrictions on celecoxib (Celebrex) use and the withdrawal of valdecoxib (Bextra)
J Cotter, E Wooltorton - Cmaj, 2005 - Can Med Assoc
Reason for posting: Coxibs, the class of NSAIDs that selectively inhibit cyclooxygenase 2
(COX-2), were designed to reduce joint pain and inflammation without causing the gastric …
(COX-2), were designed to reduce joint pain and inflammation without causing the gastric …
Safety of celecoxib compared with placebo and non-selective NSAIDs: cumulative meta-analysis of 89 randomized controlled trials
MN Essex, RY Zhang, MF Berger… - Expert opinion on …, 2013 - Taylor & Francis
Objective: Further understand the safety profile of celecoxib and provide safety information
for important adverse events (AEs). Methods: Analysis of randomized controlled trials from …
for important adverse events (AEs). Methods: Analysis of randomized controlled trials from …
Time to reappraise the therapeutic place of celecoxib
ILP Beales - Therapeutic Advances in Chronic Disease, 2018 - journals.sagepub.com
Therapeutic Advances in Chronic Disease 9 (5) 108 journals. sagepub. com/home/taj via
COX-1. 15 In keeping with this, all nonaspirin NSAIDs and coxibs12, 16 seem to increase …
COX-1. 15 In keeping with this, all nonaspirin NSAIDs and coxibs12, 16 seem to increase …
Impact of COX-2 inhibitors in common clinical practice a gastroenterologist's perspective
FS Lehmann, C Beglinger - Current topics in medicinal …, 2005 - ingentaconnect.com
Non-selective NSAIDs enhance the risk of serious ulcer complications (bleeding,
perforation, obstruction), hospitalization and death about 3-10-fold. The gastrointestinal side …
perforation, obstruction), hospitalization and death about 3-10-fold. The gastrointestinal side …
COX-2 selective nonsteroidal anti-inflammatory drugs: do they really offer any advantages?
LM Jackson, CJ Hawkey - Drugs, 2000 - Springer
Nonsteroidal anti-inflammatory drugs (NSAIDs) are responsible for substantial morbidity and
mortality as a result of the complications associated with gastroduodenal ulcers, such as …
mortality as a result of the complications associated with gastroduodenal ulcers, such as …
Celecoxib and cardiovascular risks
JM Brophy - Expert opinion on drug safety, 2005 - Taylor & Francis
In a very short time, COX-2 enzyme inhibitors have gone from the darlings to the pariahs of
the pharmaceutical industry. These drugs were developed based on the hypothesis …
the pharmaceutical industry. These drugs were developed based on the hypothesis …
Update on clinical developments with celecoxib, a new specific COX-2 inhibitor: what can we expect?
GS Geis - Scandinavian Journal of Rheumatology, 1999 - Taylor & Francis
Nonsteroidal anti-inflammatory drugs (NSAIDs) are effective for the relief of pain and
inflammation, yet their use is tempered by the development of side effects, primarily in the …
inflammation, yet their use is tempered by the development of side effects, primarily in the …
[PDF][PDF] The future of traditional nonsteroidal antiinflammatory drugs and cyclooxygenase-2 inhibitors in the treatment of inflammation and pain
MG Sciulli, ML Capone, S Tacconelli… - Pharmacological …, 2005 - academia.edu
Prostanoids act leading roles in a myriad of physiologic and pathologic processes because
these autacoids participate in the amplification of biological responses induced by …
these autacoids participate in the amplification of biological responses induced by …