Despite having been identified as the organism that causes tuberculosis in 1882,
Mycobacterium tuberculosis has managed to still evade our understanding of the protective …

Tuberculosis remains today one of the top three fatal infectious diseases, together with
acquired immune deficiency syndrome (AIDS) and malaria. During the last decade, 90 …

Mycobacterium tuberculosis remains a major public health burden. It is generally thought
that while B cell-and antibody-mediated immunity plays an important role in host defense …

Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), remains a major
worldwide health problem that causes more than 2 million deaths annually. In addition, an …

Extensive work illustrating the importance of cellular immune mechanisms for protection
against Mycobacterium tuberculosis has largely relegated B‐cell biology to an afterthought …

Mycobacterium tuberculosis is a very successful pathogen that can survive and persist in the
human host in the face of a robust immune response. This immune response is sufficient to …

Infection with Mycobacterium tuberculosis causes> 1.5 million deaths worldwide annually.
Innate immune cells are the first to encounter M. tuberculosis, and their response dictates …

Tuberculosis (TB) remains a serious global public health problem that results in up to 2
million deaths each year. TB is caused by the human pathogen, Mycobacterium tuberculosis …

The different manifestations of infection with Mycobacterium tuberculosis reflect the balance
between the bacillus and host defense mechanisms. Traditionally, protective immunity to …

The intimate and persistent connection between Mycobacterium tuberculosis and its human
host suggests that the pathogen has evolved extensive mechanisms to evade eradication by …