Exploring the interaction mechanism of chlorogenic acid and myoglobin: Insights from structure and molecular dynamics simulation

M Han, C Sun, Y Bu, W Zhu, X Li, Y Zhang, J Li - Food Chemistry, 2024 - Elsevier
This study focused on non-covalent complex of myoglobin-chlorogenic acid (Mb-CA) and
the changes in conformation, oxidation, and microstructure induced by varying …

Multispectral and molecular dynamics study on the impact of trans, trans-2, 4-decadienal and 4-hydroxy-2-nonenal on myoglobin redox stability

J Qi, X Yang, Y Cui, Y Zhang, X Luo, Y Mao, B Xu… - Food Chemistry, 2024 - Elsevier
This study investigated the interaction between myoglobin (Mb) and two lipid oxidation
products, 4-hydroxy-2-nonenal (HNE) and trans, trans-2, 4-decadienal (tt-DDE), at pH 5.6 …

Non-covalent binding of chlorogenic acid to myofibrillar protein improved its bio-functionality properties and metabolic fate

Z Zhou, D Wang, D Luo, Z Zhou, W Liu, W Zeng… - Food Chemistry, 2024 - Elsevier
As natural antioxidants added to meat products, polyphenols can interact with proteins, and
the acid-base environment influenced the extent of non-covalent and covalent interactions …

Protein–Chlorogenic Acid Interactions: Mechanisms, Characteristics, and Potential Food Applications

M Tarahi, M Gharagozlou, M Niakousari, S Hedayati - Antioxidants, 2024 - mdpi.com
The interactions between proteins and chlorogenic acid (CGA) have gained significant
attention in recent years, not only as a promising approach to modify the structural and …

Molecular mechanisms underlying the effect of lipid oxidation products on digestibility and conformation of myoglobin under thermal treatment

Y Zhuang, J Wang, L Dong, Y Zhang… - Journal of Agricultural …, 2023 - ACS Publications
Lipid oxidation can produce lipid oxidation products (LOPs), which further react with proteins
and affect their structure and digestibility, although the underlying mechanism remains …

Comparison of non-covalent binding interactions between three whey proteins and chlorogenic acid: Spectroscopic analysis and molecular docking

Y Zhang, Y Lu, Y Yang, S Li, C Wang, C Wang… - Food Bioscience, 2021 - Elsevier
Non-covalent binding interactions between three whey proteins β-lactoglobulin (β-Lg), α-
lactalbumin (α-La) and bovine serum albumin (BSA) with chlorogenic acid (CA) were …

Insight into the binding behavior, structure, and thermal stability properties of β-lactoglobulin/Amoxicillin complex in a neutral environment

S Habibian-Dehkordi, S Farhadian, M Ghasemi… - Food …, 2022 - Elsevier
Antibiotics are extensively used in agriculture and husbandry, thus threatening human
health due to their direct exposure to dairy products. Therefore, it is essential to investigate …

Investigation into the site-specific binding interactions between chlorogenic acid and ovalbumin using multi-spectroscopic and in silico simulation studies

M Perumal, P Marimuthu, X Chen - Journal of Biomolecular …, 2022 - Taylor & Francis
The binding interactions of bioactive compounds with proteins are of great importance in the
food, biochemistry and pharmaceutical fields. Herein, the binding mechanisms between 5-O …

Exploring the underlying mechanisms on NaCl-induced reduction in digestibility of myoglobin

H Liu, Q Li, S Jiang, M Zhang, D Zhao, K Shan, C Li - Food Chemistry, 2022 - Elsevier
In this paper, the structural changes of myoglobin after salt treatment and the binding mode
of substrate and pepsin/trypsin were studied by ultraviolet absorption spectroscopy …

Interaction of chlorogenic acid with milk proteins analyzed by spectroscopic and modeling methods

J Liu, Q Wang, H Zhang, D Yu, S Jin, F Ren - Spectroscopy Letters, 2016 - Taylor & Francis
Polyphenols are powerful antioxidants implicated in reducing the risk of human cancer and
cardiovascular disease. Chlorogenic acid is a principal polyphenol in coffee, a beverage …