[HTML][HTML] Potential application of sucrose acetate isobutyrate, and glyceryl monooleate for nanonization and bioavailability enhancement of rivaroxaban tablets

AA Al-Shoubki, MH Teaima, R Abdelmonem… - Pharmaceutical Science …, 2024 - Elsevier
This study aimed to investigate the use of Sucrose acetate isobutyrate (SAIB) and Glyceryl
monooleate (GMO) as co-formers for creating Cubosomes and SAIB-based nanodispersions …

Sucrose acetate isobutyrate (SAIB) and glyceryl monooleate (GMO) hybrid nanoparticles for bioavailability enhancement of rivaroxaban: an optimization study

AA Al-Shoubki, MH Teaima… - Pharmaceutical …, 2023 - Taylor & Francis
This study aims to improve the RXB bioavailability using hybrid nanoparticles. A modified
melt dispersion technique created different formulas with varying GMO-SAIB: RXB and GMO …

Enhanced biopharmaceutical performance of rivaroxaban through polymeric amorphous solid dispersion

S Metre, S Mukesh, SK Samal, M Chand… - Molecular …, 2018 - ACS Publications
Rivaroxaban (RXB) is an orally active direct inhibitor of the activated serine protease Factor
Xa, given as monotherapy in the treatment of venous thromboembolism (VTE). It has been …

Effects of polymers on the drug solubility and dissolution enhancement of poorly water-soluble rivaroxaban

MJ Choi, MR Woo, HG Choi, SG Jin - International Journal of Molecular …, 2022 - mdpi.com
The purpose of this study was to investigate the efficacy of hydrophilic polymers in a solid
dispersion formulation in improving the solubility and dissolution rate of rivaroxaban (RXB) …

Assessment of dose proportionality of rivaroxaban nanocrystals

H Demir, T Gulsun, MH Ozkan, E Nemutlu, S Sahin… - AAPS …, 2020 - Springer
Rivaroxaban (RXB) is a class II drug, according to the Biopharmaceutics Classification
System. Since its bioavailability is low at high doses, dose proportionality is not achieved for …

Enhanced oral bioavailability of Rivaroxaban-Loaded microspheres by optimizing the polymer and surfactant based on molecular interaction mechanisms

MJ Choi, MR Woo, K Baek, JH Park… - Molecular …, 2023 - ACS Publications
This study aimed to develop microspheres using water-soluble carriers and surfactants to
improve the solubility, dissolution, and oral bioavailability of rivaroxaban (RXB). RXB-loaded …

Novel rivaroxaban-loaded microsphere systems with different surface microstructure for enhanced oral bioavailability

MJ Choi, MR Woo, K Baek, JS Kim, JO Kim… - Drug Delivery and …, 2024 - Springer
This study compares rivaroxaban-loaded polymeric microsphere systems with three types of
surface microstructure. Three types of polymeric microspheres loaded with rivaroxaban were …

Preparation and optimization of rivaroxaban by self-nanoemulsifying drug delivery system (SNEDDS) for enhanced oral bioavailability and no food effect

X Xue, M Cao, L Ren, Y Qian, G Chen - Aaps Pharmscitech, 2018 - Springer
In this paper, a novel self-nanoemulsifying drug delivery system (SNEDDS) was used to
improve the oral bioavailability in fasted state and diminish the food effect for rivaroxaban …

Sustained release and enhanced oral bioavailability of rivaroxaban by PLGA nanoparticles with no food effect

MK Anwer, M Mohammad, M Iqbal, MN Ansari… - Journal of thrombosis …, 2020 - Springer
The purpose of the currents study was to enhance bioavailability of rivaroxaban (RXB) and
reduce the food effect. RXB loaded PLGA nanoparticles (RXB-PLGA-NPs) were prepared by …

Amalgamation of solid dispersion and melt adsorption techniques for augmentation of oral bioavailability of novel anticoagulant rivaroxaban

PJ Shah, MP Patel, J Shah, AB Nair, S Kotta… - Drug Delivery and …, 2022 - Springer
The objective of the present study was to evaluate the potential of solid dispersion adsorbate
(SDA) to improve the solubility and bioavailability of rivaroxaban (RXN). SDA of RXN was …