[HTML][HTML] Potential application of sucrose acetate isobutyrate, and glyceryl monooleate for nanonization and bioavailability enhancement of rivaroxaban tablets
This study aimed to investigate the use of Sucrose acetate isobutyrate (SAIB) and Glyceryl
monooleate (GMO) as co-formers for creating Cubosomes and SAIB-based nanodispersions …
monooleate (GMO) as co-formers for creating Cubosomes and SAIB-based nanodispersions …
Sucrose acetate isobutyrate (SAIB) and glyceryl monooleate (GMO) hybrid nanoparticles for bioavailability enhancement of rivaroxaban: an optimization study
AA Al-Shoubki, MH Teaima… - Pharmaceutical …, 2023 - Taylor & Francis
This study aims to improve the RXB bioavailability using hybrid nanoparticles. A modified
melt dispersion technique created different formulas with varying GMO-SAIB: RXB and GMO …
melt dispersion technique created different formulas with varying GMO-SAIB: RXB and GMO …
Enhanced biopharmaceutical performance of rivaroxaban through polymeric amorphous solid dispersion
S Metre, S Mukesh, SK Samal, M Chand… - Molecular …, 2018 - ACS Publications
Rivaroxaban (RXB) is an orally active direct inhibitor of the activated serine protease Factor
Xa, given as monotherapy in the treatment of venous thromboembolism (VTE). It has been …
Xa, given as monotherapy in the treatment of venous thromboembolism (VTE). It has been …
Effects of polymers on the drug solubility and dissolution enhancement of poorly water-soluble rivaroxaban
The purpose of this study was to investigate the efficacy of hydrophilic polymers in a solid
dispersion formulation in improving the solubility and dissolution rate of rivaroxaban (RXB) …
dispersion formulation in improving the solubility and dissolution rate of rivaroxaban (RXB) …
Assessment of dose proportionality of rivaroxaban nanocrystals
Rivaroxaban (RXB) is a class II drug, according to the Biopharmaceutics Classification
System. Since its bioavailability is low at high doses, dose proportionality is not achieved for …
System. Since its bioavailability is low at high doses, dose proportionality is not achieved for …
Enhanced oral bioavailability of Rivaroxaban-Loaded microspheres by optimizing the polymer and surfactant based on molecular interaction mechanisms
This study aimed to develop microspheres using water-soluble carriers and surfactants to
improve the solubility, dissolution, and oral bioavailability of rivaroxaban (RXB). RXB-loaded …
improve the solubility, dissolution, and oral bioavailability of rivaroxaban (RXB). RXB-loaded …
Novel rivaroxaban-loaded microsphere systems with different surface microstructure for enhanced oral bioavailability
MJ Choi, MR Woo, K Baek, JS Kim, JO Kim… - Drug Delivery and …, 2024 - Springer
This study compares rivaroxaban-loaded polymeric microsphere systems with three types of
surface microstructure. Three types of polymeric microspheres loaded with rivaroxaban were …
surface microstructure. Three types of polymeric microspheres loaded with rivaroxaban were …
Preparation and optimization of rivaroxaban by self-nanoemulsifying drug delivery system (SNEDDS) for enhanced oral bioavailability and no food effect
X Xue, M Cao, L Ren, Y Qian, G Chen - Aaps Pharmscitech, 2018 - Springer
In this paper, a novel self-nanoemulsifying drug delivery system (SNEDDS) was used to
improve the oral bioavailability in fasted state and diminish the food effect for rivaroxaban …
improve the oral bioavailability in fasted state and diminish the food effect for rivaroxaban …
Sustained release and enhanced oral bioavailability of rivaroxaban by PLGA nanoparticles with no food effect
The purpose of the currents study was to enhance bioavailability of rivaroxaban (RXB) and
reduce the food effect. RXB loaded PLGA nanoparticles (RXB-PLGA-NPs) were prepared by …
reduce the food effect. RXB loaded PLGA nanoparticles (RXB-PLGA-NPs) were prepared by …
Amalgamation of solid dispersion and melt adsorption techniques for augmentation of oral bioavailability of novel anticoagulant rivaroxaban
The objective of the present study was to evaluate the potential of solid dispersion adsorbate
(SDA) to improve the solubility and bioavailability of rivaroxaban (RXN). SDA of RXN was …
(SDA) to improve the solubility and bioavailability of rivaroxaban (RXN). SDA of RXN was …