Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous
system (CNS) with an unknown etiology, although genetic, epigenetic, and environmental …

Introduction Blood coagulation constituents might exert immunomodulatory functions in the
CNS and may trigger neuroinflammation and demyelination. We evaluated whether …

Background. Previous studies have shown impaired fibrinolysis in multiple sclerosis (MS)
and implicated extracellular proteolytic enzymes as important factors in demyelinating …

Multiple sclerosis (MS) is a prevalent neurological disease of complex etiology. Here, we
describe the characterization of a multi-incident MS family that nominated a rare missense …

Background Observational studies suggested that multiple sclerosis (MS) is associated with
cardiovascular diseases (CVDs). However, the causal association has not been fully …

Background: Thrombosis and inflammation are critical in stroke etiology, but associations of
coagulation and inflammation gene variants with stroke, and particularly factor VII levels, are …

Background: Epidemiological findings suggest a relationship between multiple sclerosis
(MS) and cardiovascular disease (CVD) risk factors, although the nature of this relationship …

Background The strong link between innate immunity and thrombosis/coagulation has
recently been investigated in the light of antibodies directed against serine proteases of the …

Background Multiple sclerosis (MS) is an autoimmune disease of the central nervous
system, with a strong genetic component. Over 100 genetic loci have been implicated in …

Background The fibrinolytic system is capable of modulating inflammatory and degenerative
events within the central nervous system. Specifically, the plasminogen activator inhibitor-1 …