Biodegradable polymeric nanoparticles increase risk of cardiovascular diseases by inducing endothelium dysfunction and inflammation

W Shi, ARM Fuad, Y Li, Y Wang, J Huang, R Du… - Journal of …, 2023 - Springer
Biodegradable polymers are expected to be an alternative to plastics. Because of its high
biocompatibility, poly (lactic-co-glycolic acid)(PLGA) is widely used in medicine. It has been …

Phagocytosis of polymeric nanoparticles aided activation of macrophages to increase atherosclerotic plaques in ApoE−/− mice

T Yin, Y Li, Y Ren, ARM Fuad, F Hu, R Du… - Journal of …, 2021 - Springer
The unique physiochemical properties of nanomaterials have been widely used in drug
delivery systems and diagnostic contrast agents. The safety issues of biomaterials with …

Anti-inflammatory nanoparticle for prevention of atherosclerotic vascular diseases

J Koga, T Matoba, K Egashira - Journal of atherosclerosis and …, 2016 - jstage.jst.go.jp
Recent technical innovation has enabled chemical modifications of small materials and
various kinds of nanoparticles have been created. In clinical settings, nanoparticle-mediated …

Long-term polystyrene nanoplastic exposure disrupt hepatic lipid metabolism and cause atherosclerosis in ApoE-/-mice

J Wen, H Sun, B Yang, E Song, Y Song - Journal of Hazardous Materials, 2024 - Elsevier
Nanoplastics (NPs) exposure is usually linked with abnormal inflammation and oxidative
stress, which are high-risk triggers of atherosclerosis; however, whether this exposure …

PLA-PEG nanoparticles improve the anti-inflammatory effect of rosiglitazone on macrophages by enhancing drug uptake compared to free rosiglitazone

G Giacalone, N Tsapis, L Mousnier, H Chacun, E Fattal - Materials, 2018 - mdpi.com
Among cardiovascular diseases, atherosclerosis remains the first cause of death in the
United States of America and Europe, as it leads to myocardial infarction or stroke. The high …

Targeted biodegradable nanoparticles for drug delivery to smooth muscle cells

S Kona, D Specht, M Rahimi, BP Shah… - … of Nanoscience and …, 2012 - ingentaconnect.com
Targeted delivery of therapeutic agents to prevent smooth muscle cell (SMC) proliferation is
important in averting restenosis (a narrowing of blood vessels). Since platelet derived …

An Emerging Role of Micro-and Nanoplastics in Vascular Diseases

SE Lee, HK Yoon, DY Kim, TS Jeong, YS Park - Life, 2024 - mdpi.com
Vascular diseases are the leading causes of death worldwide, and they are attributable to
multiple pathologies, such as atherosclerosis, diabetes, and chronic obstructive pulmonary …

Formulation and characterization of biodegradable nanoparticles for intravascular local drug delivery

CX Song, V Labhasetwar, H Murphy, X Qu… - Journal of controlled …, 1997 - Elsevier
Various drug-loaded poly (lactic-co-glycolic acid)(PLGA) nanoparticles (NP) were prepared
using an emulsification/solvent evaporation technique. Different emulsion systems were …

Biodegradable nanoparticles mimicking platelet binding as a targeted and controlled drug delivery system

S Kona, JF Dong, Y Liu, J Tan, KT Nguyen - International journal of …, 2012 - Elsevier
This research aims to develop targeted nanoparticles as drug carriers to the injured arterial
wall under fluid shear stress by mimicking the natural binding ability of platelets via …

PLLA composites combined with delivery system of bioactive agents for anti-inflammation and re-endothelialization

SW Baek, DS Kim, DH Song, S Lee, JK Lee, SY Park… - Pharmaceutics, 2022 - mdpi.com
The development of a biodegradable vascular scaffold (BVS) for the treatment of
cardiovascular diseases (CVDs) still requires some improvement. Among them, re …