Contents: 1. Introduction. 2. Genetic vs. non-genetic origin of cancer. 2.1. The limited
explanatory power of the genetic paradigm of cancer. 2.1. 1. The gene-centric approach to …

A growing number of inconsistencies have accumulated within the genetically deterministic
paradigm of the origin of cancer. Among them the most important are the nonspecific nature …

Here we contrast several carcinogenesis models. The somatic-mutation-theory posits
mutations as main causes of malignancy. However, inconsistencies led to alternative …

Cancer, the 'Emperor of All Malady'has already occupied its position in the list of most
fascinating but elusive enigmas in human history like life and consciousness. Existence of …

Cancer is a term used to define a collective set of rapidly evolving cells with immortalized
replication, altered epimetabolomes and patterns of longevity. Identifying a common …

In this article, some new aspects of unified cell bioenergetics are presented. From the
perspective of unified cell bioenergetics certain subsequent stages of cancer development …

A holistic approach to tumorigenesis is proposed. The main element of the modelis the
existence of dynamic cellular network. This network comprises a molecular and an …

Cancer is a complex disease: its pathology cannot be properly understood in terms of
independent players—genes, proteins, molecular pathways, or their simple combinations …

Single cell interactomics in simpler organisms, as well as somatic cell interactomics in
multicellular organisms, involve biomolecular interactions in complex signalling pathways …

A keystone of the molecular reductionist approach to cellular biology is a specific deductive
strategy relating genotype to phenotype—two distinct categories. This relationship is based …