Abstract Carbonic anhydrase (CA, EC 4.2. 1.1) isoforms IX and XII are overexpressed in
many hypoxic tumors as a consequence of the hypoxia inducible factor (HIF) activation …

Introduction: Human carbonic anhydrases (CA, EC 4.2. 1.1) IX and XII are tumor-associated
proteins, being part of the molecular machinery that tumor cells build as adaptive responses …

The carbonic anhydrase (CA, EC 4.2. 1.1) isozymes IX and XII are predominantly found in
tumor cells and show a restricted expression in normal tissues. By efficiently hydrating …

Introduction: Hypoxic tumors overexpress two carbonic anhydrases (CA, EC 4.2. 1.1), CA IX
and XII, involved in complex processes connected to tumorigenesis (pH regulation …

Carbonic anhydrases (CAs; EC 4.2. 1.1) are well known zinc metalloproteins involved in the
catalysis of a very simple but essential physiological reaction: carbon dioxide hydration to …

Carbonic anhydrase isoform IX (CA IX) is highly overexpressed in many types of cancer. Its
expression, which is regulated by the HIF-1 transcription factor, is strongly induced by …

Introduction Hypoxic tumors, unlike normal tissues, overexpress proteins involved in oxygen
sensing, metabolism, pH regulation, angiogenesis, immunological response, and other …

Abstract Carbonic anhydrases (CAs, EC 4.2. 1.1) are a family of enzymes widespread in all
life kingdoms. In mammals, isozyme CA IX is highly overexpressed in many cancer types …

Recent progress in understanding the role of catalytically active carbonic anhydrases in
tumors has opened new possibilities for diagnostic and/or therapeutic applications of …

Carbonic anhydrase IX (CAIX) is a hypoxia-inducible enzyme that is overexpressed by
cancer cells from many tumor types, and is a component of the pH regulatory system …