The hormonal metabolite of vitamin D, 1α, 25-dihydroxyvitamin D 3 (1, 25D), initiates
biological responses via binding to the vitamin D receptor (VDR). When occupied by 1, 25D …

The conformationally flexible secosteroid, 1α, 25 (OH) 2vitamin D3 (1α, 25 (OH) 2D3)
initiates biological responses via binding to the vitamin D receptor (VDR). The VDR contains …

The vitamin D receptor (VDR), a nuclear transcription factor, elicits physiological regulation
of gene transcription following binding of its ligand, 1, 25-dihydroxyvitamin D. The major …

Vitamin D and its' metabolites are a crucial part of the endocrine system that controls whole
body calcium homeostasis. The goal of this hormonal control is to regulate serum calcium …

Recent studies have identified a heterodimer of the vitamin D receptor (VDR) and the
retinoid X receptor (RXR) as the active complex for mediating positive transcriptional effects …

Abstract The vitamin D hormone, 1, 25‐dihydroxyvitamin D3 [1, 25 (OH) 2D3], binds with
high affinity to the nuclear vitamin D receptor (VDR), which recruits its retinoid X receptor …

IN THE DECADE SINCE THE VITAMIN Dreceptor (VDR) was cloned (1) and recognized as
a member of the superfamily of nuclear receptors that regulate gene expression in a ligand …

The vitamin D3 endocrine system serves principally to coordinate calcium and phosphorus
homeostasis through actions on the intestine, kidney, and bone (30, 32, 54, 59). The early …

Abstract The vitamin D hormone 1, 25-dihydroxyvitamin D3 [1, 25-(OH) 2D3], the biologically
active form of vitamin D, is essential for an intact mineral metabolism. Using gene targeting …

The vitamin D receptor (VDR) is the single known regulatory mediator of hormonal 1, 25-
dihydroxyvitamin D3 [1, 25 (OH) 2D3] in higher vertebrates. It acts in the nucleus of vitamin D …