Objectives Contrary to conventional MRI (cMRI), quantitative MRI (qMRI) quantifies tissue
physical microstructural properties and improves the characterization of cerebral damages …

Introduction Quantitative MRI quantifies tissue microstructural properties and supports the
characterization of cerebral tissue damages. With an MPM protocol, 4 parameter maps are …

Multiple sclerosis (MS) is an inflammatory demyelinating and neurodegenerative disorder of
the central nervous system (CNS), which stands as the most common cause of neurological …

Quantitative MR imaging techniques allow evaluating different aspects of brain
microstructure, providing meaningful information about the pathophysiology of damage in …

Multiple sclerosis (MS) is a chronic, autoimmune, inflammatory, neurological disease of the
central nervous system, which affects more than 2 million people worldwide and up to now …

Objectives Conventional MRI is not sensitive to many pathological processes underpinning
multiple sclerosis (MS) ongoing in normal appearing brain tissue (NABT). Quantitative MRI …

Despite robust postmortem evidence and potential clinical importance of gray matter (GM)
pathology in multiple sclerosis (MS), assessing GM damage by conventional magnetic …

Conventional magnetic resonance imaging of patients with multiple sclerosis provides only
limited insights into the nature of brain tissue damage with modest clinical-radiological …

Purpose Quantitative MRI (qMRI) allows assessing cortical pathology in multiple sclerosis
(MS) on a microstructural level, where cortical damage has been shown to prolong T1 …

Objective Quantitative and semi-quantitative MRI (qMRI) metrics provide complementary
specificity and differential sensitivity to pathological brain changes compatible with brain …