Preservation of acyl coenzyme A attenuates pathological and metabolic cardiac remodeling through selective lipid trafficking
Background: Metabolic remodeling in heart failure contributes to dysfunctional lipid
trafficking and lipotoxicity. Acyl coenzyme A synthetase-1 (ACSL1) facilitates long-chain fatty …
trafficking and lipotoxicity. Acyl coenzyme A synthetase-1 (ACSL1) facilitates long-chain fatty …
Acyl CoA synthetase-1 links facilitated long chain fatty acid uptake to intracellular metabolic trafficking differently in hearts of male versus female mice
JR Goldenberg, X Wang, ED Lewandowski - Journal of molecular and …, 2016 - Elsevier
Abstract Rationale Acyl CoA synthetase-1 (ACSL1) is localized at intracellular membranes,
notably the mitochondrial membrane. ACSL1 and female sex are suggested to indirectly …
notably the mitochondrial membrane. ACSL1 and female sex are suggested to indirectly …
Mouse cardiac acyl coenzyme a synthetase 1 deficiency impairs fatty acid oxidation and induces cardiac hypertrophy
JM Ellis, SM Mentock, MA DePetrillo… - … and cellular biology, 2011 - Taylor & Francis
Long-chain acyl coenzyme A (acyl-CoA) synthetase isoform 1 (ACSL1) catalyzes the
synthesis of acyl-CoA from long-chain fatty acids and contributes the majority of cardiac long …
synthesis of acyl-CoA from long-chain fatty acids and contributes the majority of cardiac long …
Cardiac energy dependence on glucose increases metabolites related to glutathione and activates metabolic genes controlled by mechanistic target of rapamycin
Background Long chain acyl‐CoA synthetases (ACSL) catalyze long‐chain fatty acids (FA)
conversion to acyl‐CoAs. Temporal ACSL 1 inactivation in mouse hearts (Acsl1 H−/−) …
conversion to acyl‐CoAs. Temporal ACSL 1 inactivation in mouse hearts (Acsl1 H−/−) …
[HTML][HTML] Acyl-CoA synthetase 1 deficiency alters cardiolipin species and impairs mitochondrial function
TJ Grevengoed, SA Martin, L Katunga, DE Cooper… - Journal of lipid …, 2015 - ASBMB
Long-chain acyl-CoA synthetase 1 (ACSL1) contributes more than 90% of total cardiac
ACSL activity, but its role in phospholipid synthesis has not been determined. Mice with an …
ACSL activity, but its role in phospholipid synthesis has not been determined. Mice with an …
[HTML][HTML] Loss of long-chain acyl-CoA synthetase isoform 1 impairs cardiac autophagy and mitochondrial structure through mechanistic target of rapamycin complex 1 …
TJ Grevengoed, DE Cooper, PA Young… - The FASEB …, 2015 - ncbi.nlm.nih.gov
Because hearts with a temporally induced knockout of acyl-CoA synthetase 1 (Acsl1 T−/−)
are virtually unable to oxidize fatty acids, glucose use increases 8-fold to compensate. This …
are virtually unable to oxidize fatty acids, glucose use increases 8-fold to compensate. This …
Deficiency of cardiac Acyl-CoA synthetase-1 induces diastolic dysfunction, but pathologic hypertrophy is reversed by rapamycin
In mice with temporally-induced cardiac-specific deficiency of acyl-CoA synthetase-1 (Acsl1
H−/−), the heart is unable to oxidize long-chain fatty acids and relies primarily on glucose for …
H−/−), the heart is unable to oxidize long-chain fatty acids and relies primarily on glucose for …
Increasing fatty acid oxidation elicits a sex-dependent response in failing mouse hearts
J Ritterhoff, TS McMillen, O Villet, S Young… - Journal of molecular and …, 2021 - Elsevier
Background Reduced fatty acid oxidation (FAO) is a hallmark of metabolic remodeling in
heart failure. Enhancing mitochondrial long-chain fatty acid uptake by Acetyl-CoA …
heart failure. Enhancing mitochondrial long-chain fatty acid uptake by Acetyl-CoA …
Targeting ACSL1 promotes cardiomyocyte proliferation and cardiac regeneration
Y Li, M Yang, J Tan, C Shen, S Deng, X Fu, S Gao, H Li… - Life Sciences, 2022 - Elsevier
Background Neonatal hearts have considerable regenerative potential within 7 days post
birth (P7), but the rate of regeneration is extremely low after P7. Interestingly, lipid …
birth (P7), but the rate of regeneration is extremely low after P7. Interestingly, lipid …
[HTML][HTML] A novel mouse model of lipotoxic cardiomyopathy
Inherited and acquired cardiomyopathies are associated with marked intracellular lipid
accumulation in the heart. To test the hypothesis that mismatch between myocardial fatty …
accumulation in the heart. To test the hypothesis that mismatch between myocardial fatty …