Large-scale neural recordings with single neuron resolution using Neuropixels probes in human cortex

AC Paulk, Y Kfir, AR Khanna, ML Mustroph… - Nature …, 2022 - nature.com
Recent advances in multi-electrode array technology have made it possible to monitor large
neuronal ensembles at cellular resolution in animal models. In humans, however, current …

Brain activity mapping at multiple scales with silicon microprobes containing 1,024 electrodes

JL Shobe, LD Claar, S Parhami… - Journal of …, 2015 - journals.physiology.org
The coordinated activity of neural ensembles across multiple interconnected regions has
been challenging to study in the mammalian brain with cellular resolution using …

[HTML][HTML] High-density single-unit human cortical recordings using the Neuropixels probe

JE Chung, KK Sellers, MK Leonard, L Gwilliams, D Xu… - Neuron, 2022 - cell.com
The action potential is a fundamental unit of neural computation. Even though significant
advances have been made in recording large numbers of individual neurons in animal …

Modified Neuropixels probes for recording human neurophysiology in the operating room

B Coughlin, W Muñoz, Y Kfir, MJ Young, D Meszéna… - Nature …, 2023 - nature.com
Neuropixels are silicon-based electrophysiology-recording probes with high channel count
and recording-site density. These probes offer a turnkey platform for measuring neural …

Acute head-fixed recordings in awake mice with multiple Neuropixels probes

S Durand, GR Heller, TK Ramirez, JA Luviano… - Nature …, 2023 - nature.com
Multi-electrode arrays such as Neuropixels probes enable electrophysiological recordings
from large populations of single neurons with high temporal resolution. By using such …

Large-scale high-density brain-wide neural recording in nonhuman primates

EM Trautmann, JK Hesse, GM Stine, R Xia, S Zhu… - BioRxiv, 2023 - biorxiv.org
High-density, integrated silicon electrodes have begun to transform systems neuroscience,
by enabling large-scale neural population recordings with single cell resolution. Existing …

Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings

NA Steinmetz, C Aydin, A Lebedeva, M Okun… - Science, 2021 - science.org
INTRODUCTION Electrode arrays based on complementary metal-oxide semiconductor
silicon fabrication technology, such as Neuropixels probes, have enabled recordings of …

[HTML][HTML] Challenges and opportunities for large-scale electrophysiology with Neuropixels probes

NA Steinmetz, C Koch, KD Harris… - Current opinion in …, 2018 - Elsevier
Electrophysiological methods are the gold standard in neuroscience because they reveal
the activity of individual neurons at high temporal resolution and in arbitrary brain locations …

High-resolution three-dimensional extracellular recording of neuronal activity with microfabricated electrode arrays

J Du, IH Riedel-Kruse, JC Nawroth… - Journal of …, 2009 - journals.physiology.org
Microelectrode array recordings of neuronal activity present significant opportunities for
studying the brain with single-cell and spike-time precision. However, challenges in device …

Nanofabricated ultraflexible electrode arrays for high‐density intracortical recording

X Wei, L Luan, Z Zhao, X Li, H Zhu, O Potnis… - Advanced …, 2018 - Wiley Online Library
Understanding brain functions at the circuit level requires time‐resolved simultaneous
measurement of a large number of densely distributed neurons, which remains a great …