Transferrin-Pep63-liposomes accelerate the clearance of Aβ and rescue impaired synaptic plasticity in early Alzheimer's disease models
X Yang, X Li, L Liu, YH Chen, Y You, Y Gao… - Cell Death …, 2021 - nature.com
Alzheimer's disease (AD) is characterized by aberrant accumulation of extracellular β-
amyloid (Aβ) peptides in the brain. Soluble Aβ oligomers are thought to be the most …
amyloid (Aβ) peptides in the brain. Soluble Aβ oligomers are thought to be the most …
Multifunctional liposomes reduce brain β-amyloid burden and ameliorate memory impairment in Alzheimer's disease mouse models
C Balducci, S Mancini, S Minniti… - Journal of …, 2014 - Soc Neuroscience
Alzheimer's disease is characterized by the accumulation and deposition of plaques of β-
amyloid (Aβ) peptide in the brain. Given its pivotal role, new therapies targeting Aβ are in …
amyloid (Aβ) peptide in the brain. Given its pivotal role, new therapies targeting Aβ are in …
Liposomes bi-functionalized with phosphatidic acid and an ApoE-derived peptide affect Aβ aggregation features and cross the blood–brain-barrier: Implications for …
L Bana, S Minniti, E Salvati, S Sesana… - … , Biology and Medicine, 2014 - Elsevier
Targeting amyloid-β peptide (Aβ) within the brain is a strategy actively sought for therapy of
Alzheimer's disease (AD). We investigated the ability of liposomes bi-functionalized with …
Alzheimer's disease (AD). We investigated the ability of liposomes bi-functionalized with …
Liposome delivery systems for the treatment of Alzheimer's disease
C Ross, M Taylor, N Fullwood… - International journal of …, 2018 - Taylor & Francis
Alzheimer's disease (AD) will affect around 115 million people worldwide by the year 2050.
It is associated with the accumulation of misfolded and aggregated proteins (β-amyloid and …
It is associated with the accumulation of misfolded and aggregated proteins (β-amyloid and …
The hunt for brain Aβ oligomers by peripherally circulating multi-functional nanoparticles: Potential therapeutic approach for Alzheimer disease
We previously showed the ability of liposomes bi-functionalized with phosphatidic acid and
an ApoE-derived peptide (mApoE-PA-LIP) to reduce brain Aβ in transgenic Alzheimer mice …
an ApoE-derived peptide (mApoE-PA-LIP) to reduce brain Aβ in transgenic Alzheimer mice …
Liposomes functionalized with acidic lipids rescue Aβ-induced toxicity in murine neuroblastoma cells
E Bereczki, F Re, ME Masserini, B Winblad… - … , Biology and Medicine, 2011 - Elsevier
The loss of synapses and neurons in Alzheimer's disease (AD) is thought to be at least partly
induced by toxic species formed by the amyloid beta (Aβ) peptide; therefore, therapeutics …
induced by toxic species formed by the amyloid beta (Aβ) peptide; therefore, therapeutics …
Multifunctional Liposomes Targeting Amyloid‐β Oligomers for Early Diagnosis and Therapy of Alzheimer's Disease
Early detection and treatment are crucial for Alzheimer's disease (AD) management. Current
diagnostic and therapeutic methods focus on late‐stage amyloid fibrils and plaques …
diagnostic and therapeutic methods focus on late‐stage amyloid fibrils and plaques …
Identification of polyphenolic compounds and black tea extract as potent inhibitors of lipid membrane destabilization by Aβ 42 aggregates
Amyloid-β (Aβ) aggregation is a recognized key process in the pathogenesis of Alzheimer's
disease (AD). Misfolded Aβ peptides self-assemble into higher-order oligomers that …
disease (AD). Misfolded Aβ peptides self-assemble into higher-order oligomers that …
Inhibition of amyloid beta-induced synaptotoxicity by a pentapeptide derived from the glycine zipper region of the neurotoxic peptide
C Peters, EJ Fernandez-Perez, CF Burgos… - Neurobiology of …, 2013 - Elsevier
A major characteristic of Alzheimer's disease is the presence of amyloid beta (Aβ) oligomers
and aggregates in the brain. Aβ oligomers interact with the neuronal membrane inducing …
and aggregates in the brain. Aβ oligomers interact with the neuronal membrane inducing …
Multifunctional liposomes interact with Abeta in human biological fluids: Therapeutic implications for Alzheimer's disease
The accumulation of extracellular amyloid beta (Abeta42) both in brain and in cerebral
vessels characterizes Alzheimer's disease (AD) pathogenesis. Recently, the possibility to …
vessels characterizes Alzheimer's disease (AD) pathogenesis. Recently, the possibility to …