Pregnancy and neonatal outcomes after fetal exposure to biologics and thiopurines among women with inflammatory bowel disease

U Mahadevan, MD Long, SV Kane, A Roy… - Gastroenterology, 2021 - Elsevier
Background & Aims Pregnant women with inflammatory bowel disease (IBD) may require
biologic or thiopurine therapy to control disease activity. Lack of safety data has led to …

Systematic review and meta-analysis on the effects of thiopurines on birth outcomes from female and male patients with inflammatory bowel disease

M Akbari, S Shah, FS Velayos… - Inflammatory bowel …, 2013 - academic.oup.com
Background Inflammatory bowel disease (IBD) affects people during their prime
reproductive years. The thiopurines (6-mercaptopurine and azathioprine), commonly used …

The fetal safety of thiopurines for the treatment of inflammatory bowel disease in pregnancy

JR Hutson, JN Matlow, ME Moretti… - Journal of Obstetrics and …, 2013 - Taylor & Francis
Maintaining remission of inflammatory bowel disease (IBD) during pregnancy is critical for
positive pregnancy outcomes. Conflicting data exist regarding the association between …

Use of thiopurines during conception and pregnancy is not associated with adverse pregnancy outcomes or health of infants at one year in a prospective study

SL Kanis, A de Lima-Karagiannis, NKH de Boer… - Clinical …, 2017 - Elsevier
Background & Aims Most data on the safety of thiopurine therapy for inflammatory bowel
disease (IBD) during pregnancy come from retrospective studies, which makes it difficult to …

Pregnancy outcome in patients with inflammatory bowel disease treated with thiopurines: cohort from the CESAME Study

J Coelho, L Beaugerie, JF Colombel, X Hébuterne… - Gut, 2011 - gut.bmj.com
Background and aims Few studies have been conducted addressing the safety of thiopurine
treatment in pregnant women with inflammatory bowel disease (IBD). The aim of this study …

Safety of thiopurines and anti-TNF-α drugs during pregnancy in patients with inflammatory bowel disease

MJ Casanova, M Chaparro, E Domenech… - Official journal of the …, 2013 - journals.lww.com
OBJECTIVES: The safety of thiopurines and anti-tumor necrosis factor-α (TNF-α) drugs
during pregnancy remains controversial, as the experience with these drugs in this situation …

Outcomes of pregnancies fathered by inflammatory bowel disease patients exposed to thiopurines

C Teruel, A López-San Román, F Bermejo… - Official journal of the …, 2010 - journals.lww.com
OBJECTIVES: Immunomodulators are used as maintenance treatment of inflammatory
bowel disease (IBD). Data regarding their possible effects in the course of pregnancy when …

Birth outcomes in women with inflammatory bowel disease: effects of disease activity and drug exposure

G Bröms, F Granath, M Linder… - Inflammatory bowel …, 2014 - academic.oup.com
Background Ulcerative colitis (UC) and Crohn's disease (CD) have been associated with
increased risks of adverse birth outcomes. Disease activity and drug exposure may …

Health outcomes of 1000 children born to mothers with inflammatory bowel disease in their first 5 years of life

SL Kanis, S Modderman, JC Escher, N Erler… - Gut, 2021 - gut.bmj.com
Objective The aim of this study was to describe the long-term health outcomes of children
born to mothers with inflammatory bowel disease (IBD) and to assess the impact of maternal …

Long‐term follow‐up of children exposed intrauterine to maternal thiopurine therapy during pregnancy in females with inflammatory bowel disease

TGJ De Meij, B Jharap, CMF Kneepkens… - Alimentary …, 2013 - Wiley Online Library
Background Inflammatory bowel disease (IBD) affects a substantial number of female
patients in their reproductive years. Therefore, many physicians face the dilemma whether …