Circulating tumor cells: technologies and their clinical potential in cancer metastasis

J Xiao, PR Pohlmann, C Isaacs, BA Weinberg, AR He… - Biomedicines, 2021 - mdpi.com
Circulating tumor cells (CTCs) are single cells or clusters of cells within the circulatory
system of a cancer patient. While most CTCs will perish, a small proportion will proceed to …

Circulating tumour cells—a bona fide cause of metastatic cancer

NJ Caixeiro, N Kienzle, SH Lim, KJ Spring… - Cancer and Metastasis …, 2014 - Springer
Circulating tumour cells (CTCs) are emerging as important prognostic markers and have
potential clinical utility as tumour biomarkers for targeted cancer therapy. Although CTCs …

Circulating tumor cells: from bench to bedside

M Balic, A Williams, H Lin, R Datar… - Annual review of …, 2013 - annualreviews.org
Circulating tumor cells (CTCs) represent a surrogate biomarker of hematogenous
metastases. In recent years, their detection has gained increasing interest. There is ample …

Circulating tumor cells: utopia or reality?

V Conteduca, R Zamarchi, E Rossi, V Condelli… - Future …, 2013 - Taylor & Francis
Circulating tumor cells (CTCs) could be considered a sign of tumor aggressiveness, but
highly sensitive and specific methods of CTC detection are necessary owing to the rarity and …

Utilizing circulating tumor cells: challenges and pitfalls

G Attard, JS de Bono - Current opinion in genetics & development, 2011 - Elsevier
Circulating tumor cells (CTC) detected in the blood of cancer patients could be used for risk-
stratification, molecular subclassification and as an intermediate end-point in therapeutic …

Circulating tumor cells: the substrate of personalized medicine?

BT Greene, AD Hughes, MR King - Frontiers in oncology, 2012 - frontiersin.org
Circulating tumor cells (CTCs) are believed to be responsible for the development of
metastatic disease. Over the last several years there has been a great interest in …

The role of circulating tumor cells in the metastatic cascade: biology, technical challenges, and clinical relevance

H Dianat-Moghadam, M Azizi, Z Eslami-S… - Cancers, 2020 - mdpi.com
Metastases and cancer recurrence are the main causes of cancer death. Circulating Tumor
Cells (CTCs) and disseminated tumor cells are the drivers of cancer cell dissemination. The …

Preclinical models to study patient-derived circulating tumor cells and metastasis

KN Suvilesh, Y Manjunath, K Pantel, JT Kaifi - Trends in Cancer, 2023 - cell.com
Circulating tumor cells (CTCs) that are detached from the tumor can be precursors of
metastasis. The majority of studies focus on enumeration of CTCs from patient blood to …

Looking back, to the future of circulating tumor cells

TW Friedlander, G Premasekharan, PL Paris - Pharmacology & therapeutics, 2014 - Elsevier
Detection and analysis of circulating tumor cells (CTCs) from patients with metastatic
malignancies have become active areas of research in recent years. CTC enumeration has …

Circulating tumor cells

SA García, J Weitz, S Schölch - Cancer stem cells: Methods and protocols, 2018 - Springer
In most solid tumors, it is distant metastases rather than the primary tumor which limit the
prognosis. Distant metastases are caused by circulating tumor cells (CTCs) which actively …